Side Effects of Opioids Are Ameliorated by Regulating TRPV1 Receptors
文献类型:期刊论文
作者 | Xiaqing Wang1,2; Chongyu Bao1,2; Zhenjiang Li1; Lupeng Yue1,2; Li Hu1,2 |
刊名 | INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH |
出版日期 | 2022 |
卷号 | 19期号:4页码:11 |
关键词 | TRPV1 µ-opioid opioid side effects neuropathic pain β-arrestin2 |
DOI | 10.3390/ijerph19042387 |
通讯作者 | Yue, Lupeng(huli@psych.ac.cn) ; Hu, Li(huli@psych.ac.cn) |
产权排序 | 1 |
文献子类 | 综述 |
英文摘要 | Humans have used opioids to suppress moderate to severe pain for thousands of years. However, the long-term use of opioids has several adverse effects, such as opioid tolerance, opioid-induced hyperalgesia, and addiction. In addition, the low efficiency of opioids in controlling neuropathic pain limits their clinical applications. Combining nonopioid analgesics with opioids to target multiple sites along the nociceptive pathway may alleviate the side effects of opioids. This study reviews the feasibility of reducing opioid side effects by regulating the transient receptor potential vanilloid 1 (TRPV1) receptors and summarizes the possible underlying mechanisms. Blocking and activating TRPV1 receptors can improve the therapeutic profile of opioids in different manners. TRPV1 and mu-opioid receptors are bidirectionally regulated by beta-arrestin2. Thus, drug combinations or developing dual-acting drugs simultaneously targeting mu-opioid and TRPV1 receptors may mitigate opioid tolerance and opioid-induced hyperalgesia. In addition, TRPV1 receptors, especially expressed in the dorsal striatum and nucleus accumbens, participate in mediating opioid reward, and its regulation can reduce the risk of opioid-induced addiction. Finally, co-administration of TRPV1 antagonists and opioids in the primary action sites of the periphery can significantly relieve neuropathic pain. In general, the regulation of TRPV1 may potentially ameliorate the side effects of opioids and enhance their analgesic efficacy in neuropathic pain. |
收录类别 | EI |
WOS关键词 | POSTOPERATIVE PAIN MANAGEMENT ; NEUROPATHIC PAIN ; SYSTEMIC MORPHINE ; SENSORY NEURONS ; INDUCED TOLERANCE ; PLACE PREFERENCE ; ANTAGONIST ; EXPRESSION ; MODEL ; ACTIVATION |
资助项目 | National Natural Science Foundation of China[32071061] ; National Natural Science Foundation of China[31822025] ; National Natural Science Foundation of China[32000749] ; Scientific Foundation of the Institute of Psychology, Chinese Academy of Science[2020000197] |
WOS研究方向 | Environmental Sciences & Ecology ; Public, Environmental & Occupational Health |
语种 | 英语 |
出版者 | MDPI |
WOS记录号 | WOS:000773060000001 |
资助机构 | National Natural Science Foundation of China ; Scientific Foundation of the Institute of Psychology, Chinese Academy of Science |
源URL | [http://ir.psych.ac.cn/handle/311026/42165] |
专题 | 心理研究所_中国科学院心理健康重点实验室 |
作者单位 | 1.CAS Key Laboratory of Mental Health, Institute of Psychology, Beijing 100101, China 2.Department of Psychology, University of Chinese Academy of Sciences, Beijing 100049, China |
推荐引用方式 GB/T 7714 | Xiaqing Wang,Chongyu Bao,Zhenjiang Li,et al. Side Effects of Opioids Are Ameliorated by Regulating TRPV1 Receptors[J]. INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH,2022,19(4):11. |
APA | Xiaqing Wang,Chongyu Bao,Zhenjiang Li,Lupeng Yue,&Li Hu.(2022).Side Effects of Opioids Are Ameliorated by Regulating TRPV1 Receptors.INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH,19(4),11. |
MLA | Xiaqing Wang,et al."Side Effects of Opioids Are Ameliorated by Regulating TRPV1 Receptors".INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH 19.4(2022):11. |
入库方式: OAI收割
来源:心理研究所
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