Association between the CLOCK gene polymorphism and depressive symptom mediated by sleep quality among non-clinical Chinese Han population
文献类型：期刊论文
| 作者 | Li, Yuling1; Cao, Zeyuan1; Wu, Shuang1; Wang, Chao1; Dong, Yan2; Zhao, Ning O.3; He, Shuchang1; Zhang, Xiangyang4,5
|
| 刊名 | JOURNAL OF AFFECTIVE DISORDERS
 |
| 出版日期 | 2022-02-01 |
| 卷号 | 298页码:217-223 |
| ISSN号 | 0165-0327 |
| 关键词 | Depressive symptom Sleep quality CLOCK SNP Rsl 2649507 |
| DOI | 10.1016/j.jad.2021.10.070 |
| 通讯作者 | Dong, Yan(dong8958@126.com) ; He, Shuchang(shuchangh@pku.edu.cn) ; Zhang, Xiangyang(zhangxy@psych.ac.cn) |
| 英文摘要 | Background: Depression is a common mental disorder associated with sleep problems and the circadian clock genes may underlie the relationship between the two in clinical samples. However, little is known about whether poor sleep quality is associated with depressive symptom in healthy individuals and whether is mediated by specific single-nucleotide polymorphisms (SNPs). Methods: Using a cross-sectional design, 444 university staff members were randomly recruited in Beijing. We used the Pittsburgh Sleep Quality Index (PSQI) to measure sleep quality, the Zung's Self-rating Depression Scale (SDS) to measure depressive symptom, and the Work Stress Scale to measure job stress. The CLOCK gene rsl 2649507 polymorphism was genotyped in 289 blood samples. Results: There were positive inter-correlations between job stress, PSQI and SDS (almost ps < 0.05). GG homozygotes of the SNP had higher PSQI and its sleep duration and daytime dysfunction scores than AA homozygotes (all Bonferroni corrected ps0.05). The SNP had no main effect on the SDS and did not interact with job stress to affect SDS, PSQI and its dimensions (all ps > 0.05). Interestingly, after controlling for job stress and covariates, the significant effect size of the SNP on the SDS mediated by the PSQI was 0.68 (95% CI [0.24, 1.35]). Limitations: Some limitations included single professional background, cross-sectional study design, small sample size and potential confounding factors, which could be amended by future research. Conclusions: Non-clinical Chinese carrying CLOCK gene rsl 2649507 G-allele may lead to poor sleep quality and further depression symptoms. |
| 收录类别 | SCI |
| WOS关键词 | MAJOR DEPRESSION ; ADOLESCENTS ; DISORDERS ; DISTURBANCES ; PATTERNS ; UNIPOLAR ; MODEL ; INDEX ; AXIS ; CRY1 |
| 资助项目 | National Natural Science Foundation of China[81871060] |
| WOS研究方向 | Neurosciences & Neurology ; Psychiatry |
| 语种 | 英语 |
| 出版者 | ELSEVIER |
| WOS记录号 | WOS:000768324700027 |
| 资助机构 | National Natural Science Foundation of China |
| 源URL | [http://ir.psych.ac.cn/handle/311026/42185]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 通讯作者 | Dong, Yan; He, Shuchang; Zhang, Xiangyang |
| 作者单位 | 1.Peking Univ, Sch Psychol & Cognit Sci, Beijing, Peoples R China 2.Peking Univ, Beijing Key Lab Behav & Mental Hlth, Beijing, Peoples R China 3.Renmin Univ China, Dept Psychol, Beijing, Peoples R China 4.Univ Texas Hlth Sci Ctr Houston, Dept Psychiat & Behav Sci, Houston, TX 77030 USA 5.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Yuling,Cao, Zeyuan,Wu, Shuang,et al. Association between the CLOCK gene polymorphism and depressive symptom mediated by sleep quality among non-clinical Chinese Han population[J]. JOURNAL OF AFFECTIVE DISORDERS,2022,298:217-223. |
| APA | Li, Yuling.,Cao, Zeyuan.,Wu, Shuang.,Wang, Chao.,Dong, Yan.,...&Zhang, Xiangyang.(2022).Association between the CLOCK gene polymorphism and depressive symptom mediated by sleep quality among non-clinical Chinese Han population.JOURNAL OF AFFECTIVE DISORDERS,298,217-223. |
| MLA | Li, Yuling,et al."Association between the CLOCK gene polymorphism and depressive symptom mediated by sleep quality among non-clinical Chinese Han population".JOURNAL OF AFFECTIVE DISORDERS 298(2022):217-223. |
入库方式： OAI收割
来源：心理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。