Neural processes responsible for the translation of sustained nociceptive inputs into subjective pain experience
文献类型：期刊论文
| 作者 | Wang, Hailu1,2; Guo, Yifei3,4 ; Tu, Yiheng1,2; Peng, Weiwei5; Lu, Xuejing1,2; Bi, Yanzhi1,2; Iannetti, Gian Domenico3,4; Hu, Li1,2
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| 刊名 | CEREBRAL CORTEX
 |
| 出版日期 | 2022-03-04 |
| 页码 | 17 |
| 关键词 | nociceptive information pain perception alpha-band oscillations phase-amplitude coupling mediation effects |
| ISSN号 | 1047-3211 |
| DOI | 10.1093/cercor/bhac090 |
| 通讯作者 | Hu, Li(huli@psych.ac.cn) |
| 英文摘要 | Tracking and predicting the temporal structure of nociceptive inputs is crucial to promote survival, as proper and immediate reactions are necessary to avoid actual or potential bodily injury. Neural activities elicited by nociceptive stimuli with different temporal structures have been described, but the neural processes responsible for translating nociception into pain perception are not fully elucidated. To tap into this issue, we recorded electroencephalographic signals from 48 healthy participants receiving thermo-nociceptive stimuli with 3 different durations and 2 different intensities. We observed that pain perception and several brain responses are modulated by stimulus duration and intensity. Crucially, we identified 2 sustained brain responses that were related to the emergence of painful percepts: a low-frequency component (LFC, < 1 Hz) originated from the insula and anterior cingulate cortex, and an alpha-band event-related desynchronization (alpha-ERD, 8-13 Hz) generated from the sensorimotor cortex. These 2 sustained brain responses were highly coupled, with the alpha-oscillation amplitude that fluctuated with the LFC phase. Furthermore, the translation of stimulus duration into pain perception was serially mediated by alpha-ERD and LFC. The present study reveals how brain responses elicited by nociceptive stimulation reflect the complex processes occurring during the translation of nociceptive information into pain perception. |
| 收录类别 | SCI |
| WOS关键词 | C-FIBER ; EVOKED POTENTIALS ; EEG RESPONSES ; A-DELTA ; HEAT ; STIMULATION ; FREQUENCY ; SKIN ; SYNCHRONIZATION ; OSCILLATIONS |
| 资助项目 | National Natural Science Foundation of China[32071061and31822025] ; ERC Consolidator Grant(PAINSTRAT) |
| WOS研究方向 | Neurosciences & Neurology |
| 语种 | 英语 |
| WOS记录号 | WOS:000764111000001 |
| 出版者 | OXFORD UNIV PRESS INC |
| 资助机构 | National Natural Science Foundation of China ; ERC Consolidator Grant(PAINSTRAT) |
| 源URL | [http://ir.psych.ac.cn/handle/311026/42188]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 通讯作者 | Hu, Li |
| 作者单位 | 1.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing 100101, Peoples R China 2.Univ Chinese Acad Sci, Dept Psychol, Beijing 100049, Peoples R China 3.Ist Italiano Tecnol, Neurosci & Behav Lab, I-3016163 Rome, Italy 4.UCL, Dept Neurosci Physiol & Pharmacol, London WC1E 6BT, England 5.Shenzhen Univ, Brain Funct & Psychol Sci Res Ctr, Shenzhen 518061, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Hailu,Guo, Yifei,Tu, Yiheng,et al. Neural processes responsible for the translation of sustained nociceptive inputs into subjective pain experience[J]. CEREBRAL CORTEX,2022:17. |
| APA | Wang, Hailu.,Guo, Yifei.,Tu, Yiheng.,Peng, Weiwei.,Lu, Xuejing.,...&Hu, Li.(2022).Neural processes responsible for the translation of sustained nociceptive inputs into subjective pain experience.CEREBRAL CORTEX,17. |
| MLA | Wang, Hailu,et al."Neural processes responsible for the translation of sustained nociceptive inputs into subjective pain experience".CEREBRAL CORTEX (2022):17. |
入库方式： OAI收割
来源：心理研究所
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