Adolescent chronic unpredictable stress causes a bias in goal-directed behavior and distinctively changes the expression of NMDA and dopamine receptors in the dorsomedial and dorsolateral striatum in male rats
文献类型：期刊论文
| 作者 | Wu, Chao1,2; Zheng, Wei1,2; Jia, Xiaohua3; Li, Yonghui1,2 ; Shen, Fang1,2; Haghparast, Abbas4; Liang, Jing1,2; Sui, Nan1,2; Zhang, Jian-Jun1,2
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| 刊名 | DEVELOPMENTAL PSYCHOBIOLOGY
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| 出版日期 | 2022-03-01 |
| 卷号 | 64期号:2页码:10 |
| 关键词 | adolescent chronic unpredictable stress dorsolateral striatum goal-directed behavior NR2B receptor |
| ISSN号 | 0012-1630 |
| DOI | 10.1002/dev.22235 |
| 通讯作者 | Zhang, Jian-Jun(zhangjj@psych.ac.cn) |
| 英文摘要 | The distinct preferences between goal-directed and habit-directed behaviors involve numerous neurodegenerative and psychiatric disorders. Chronic stress during adulthood biases behavior toward habit-oriented strategies. However, it remains to be studied how adolescence, as a stage in which brain regions are still undergoing development, suffering stress will affect this preference. Here, we exposed rats to chronic unpredictable stress (CUS) at PND 21 to PND 33 and PND 34 to PND 47 to examine its effect on sugar pellet-based instrumental behavior in adulthood. We showed that rats exposed to CUS in middle adolescence had a biased goal-directed strategy rather than a habit-oriented strategy in adulthood, whereas CUS exposure in early adolescence did not have this effect. Moreover, middle adolescent CUS caused the downregulation of the N-methyl-d-aspartate receptor subtype 2 B (NR2B) in the dorsolateral striatum (DLS) rather than in the dorsomedial striatum (DMS), whereas no change was observed in NR2A or the dopamine D1 receptor (D1R) or the dopamine D2 receptor (D2R) in the DLS. Together, these findings suggest that CUS in middle adolescence inhibits habitual behavior in adulthood and downregulates the expression of NR2B in DLS, providing new evidence to understand the molecular mechanisms of abnormal habitual behaviors induced by adolescent stress. |
| 收录类别 | SCI |
| WOS关键词 | HABITUAL COCAINE-SEEKING ; MEDIAL PREFRONTAL CORTEX ; SOCIAL DEFEAT ; RESPONSES ; NEURONS ; PERIOD ; NR2B ; BDNF |
| 资助项目 | National Natural Science Foundation of China[31871111] ; National Natural Science Foundation of China[31400880] ; CAS-VPST Silk Road Science Fund 2021[GJHZ202129] ; Youth Innovation Promotion Association CAS[2020088] ; Beijing Tianjin-Hebei Basic Research Cooperation Special Program[19JCZDJC65300] ; CAS Key Laboratory of Mental Health Grant[KLMH2020K02] |
| WOS研究方向 | Developmental Biology ; Psychology |
| 语种 | 英语 |
| WOS记录号 | WOS:000759041700002 |
| 出版者 | WILEY |
| 资助机构 | National Natural Science Foundation of China ; CAS-VPST Silk Road Science Fund 2021 ; Youth Innovation Promotion Association CAS ; Beijing Tianjin-Hebei Basic Research Cooperation Special Program ; CAS Key Laboratory of Mental Health Grant |
| 源URL | [http://ir.psych.ac.cn/handle/311026/42206]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 通讯作者 | Zhang, Jian-Jun |
| 作者单位 | 1.Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China 2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 3.Chinese Acad Sci, Key Lab Mol Imaging, Inst Automat, Beijing, Peoples R China 4.Shahid Beheshti Univ Med Sci, Neurosci Res Ctr, Sch Med, Tehran, Iran |
| 推荐引用方式 GB/T 7714 | Wu, Chao,Zheng, Wei,Jia, Xiaohua,et al. Adolescent chronic unpredictable stress causes a bias in goal-directed behavior and distinctively changes the expression of NMDA and dopamine receptors in the dorsomedial and dorsolateral striatum in male rats[J]. DEVELOPMENTAL PSYCHOBIOLOGY,2022,64(2):10. |
| APA | Wu, Chao.,Zheng, Wei.,Jia, Xiaohua.,Li, Yonghui.,Shen, Fang.,...&Zhang, Jian-Jun.(2022).Adolescent chronic unpredictable stress causes a bias in goal-directed behavior and distinctively changes the expression of NMDA and dopamine receptors in the dorsomedial and dorsolateral striatum in male rats.DEVELOPMENTAL PSYCHOBIOLOGY,64(2),10. |
| MLA | Wu, Chao,et al."Adolescent chronic unpredictable stress causes a bias in goal-directed behavior and distinctively changes the expression of NMDA and dopamine receptors in the dorsomedial and dorsolateral striatum in male rats".DEVELOPMENTAL PSYCHOBIOLOGY 64.2(2022):10. |
入库方式： OAI收割
来源：心理研究所
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