Chronic pain is one of the major physical and mental disorders within the scope of the world,causes the physical and psychological discomfort and significantly increases the medical costs.Taking neuropathic pain(PN)as an example,this article overviews the specific mechanism of chronic pain related to nerve injury and the neurophysiological mechanism shared with the chronic process,and further clarifies the regulation of the hypothalamic-pituitary-adrenal cortex(HPA)axis on the remodeling of central nervous system structure and function during the process of chronic pain.The purpose of this paper is to promote the understanding of the pain mechanism,so as to help monitor and prevent the occurrence and development of chronic pain,and to provide the theoretical reference for targeted medicine based on the mechanism.

摘要： 慢性疼痛是世界范围内主要的身心障碍之一,其会引起患者生理和心理的不适感,并大幅增加医疗费用.本文将以神经病理性疼痛(NP)为例,概述慢性疼痛与神经损伤相关的特异性机制及与慢性化过程中共享的神经生理机制,并进一步阐明下丘脑-垂体-肾上腺皮质(HPA)轴在疼痛慢性化过程中对中枢神经系统结构和功能重塑的调控.本文旨在促进对疼痛机制的认识,从而有助于监测和预防慢性疼痛的发生和发展,并为基于机制的靶向医疗提供理论参考.

国家自然科学基金面上项目(31471082,31671141) 重庆市基础科学与前沿技术研究一般项目(cstc2Ol5jcyjA10056)