Serum NLRP3 Inflammasome and BDNF: Potential Biomarkers Differentiating Reactive and Endogenous Depression
文献类型：期刊论文
| 作者 | Yang, Xin-Jing1,2; Zhao, Bing-Cong3; Li, Jing4 ; Shi, Chuan5; Song, Yu-Qing6; Gao, Xing-Zhou7; Jiang, Hui-Li7; Yu, Qiu-Yun8; Liang, Xing-Chen9; Feng, Shi-Xing10
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| 刊名 | FRONTIERS IN PSYCHIATRY
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| 出版日期 | 2022-02-28 |
| 卷号 | 13页码:8 |
| 关键词 | mild-to-moderate depression reactive depression endogenous depression NOD-like receptor family protein 3 (NLRP3) brain-derived neurotrophic factor (BDNF) |
| ISSN号 | 1664-0640 |
| DOI | 10.3389/fpsyt.2022.814828 |
| 通讯作者 | Bao, Tuya(tuyab@263.net) ; Zhang, Zhang-Jin(zhangzj@hku.hk) |
| 英文摘要 | BackgroundThe highly heterogeneous pathogenesis of depression and limited response to current antidepressants call for more objective evidence for depression subtypes. Reactive and endogenous depression are two etiologically distinct subtypes associated with different treatment responses. This study aims to explore the potential biomarkers that differentiate reactive and endogenous depressions. MethodsThe clinical manifestations and biological indicators of 64 unmedicated mild-to-moderate depression patients (32 reactive depression patients and 32 endogenous depression patients) and 21 healthy subjects were observed. The 24-item Hamilton rating scale for depression (HAMD-24) was used to evaluate the severity of depression. Serum levels of depression-related biological indicators were measured by using the enzyme-linked immunosorbent assay. ResultsThe NLRP3 level of reactive depression was significantly lower than those of endogenous depression and healthy controls. There was a significant negative correlation between the BDNF level and the HAMD-24 total scores for patients with reactive depression. ConclusionOur findings suggested the serum NLRP3 and BDNF levels could be potential biomarkers for detecting and evaluating the severity of reactive depression. |
| 收录类别 | SCI |
| WOS关键词 | MAJOR DEPRESSION ; MOOD DISORDERS ; PATHOPHYSIOLOGY ; METAANALYSIS ; ACTIVATION |
| 资助项目 | National Natural Science Foundation of China[81574070] ; National Natural Science Foundation of China[82004445] |
| WOS研究方向 | Psychiatry |
| 语种 | 英语 |
| WOS记录号 | WOS:000772633600001 |
| 出版者 | FRONTIERS MEDIA SA |
| 资助机构 | National Natural Science Foundation of China |
| 源URL | [http://ir.psych.ac.cn/handle/311026/42306]  |
| 专题 | 心理研究所_认知与发展心理学研究室 |
| 通讯作者 | Bao, Tuya; Zhang, Zhang-Jin |
| 作者单位 | 1.Shenzhen Univ, South China Hosp, Dept Tradit Chinese Med, Shenzhen, Peoples R China 2.Univ Hong Kong, Li Ka Shing Fac Med, Sch Chinese Med, Hong Kong, Peoples R China 3.Capital Med Univ, Beijing Hosp Tradit Chinese Med, Acupuncture & Moxibust Dept, Beijing Key Lab Acupuncture Neuromodulat, Beijing, Peoples R China 4.Chinese Acad Sci, Inst Psychol, Ctr Aging Psychol, Beijing, Peoples R China 5.Peking Univ, Hosp 6, Psychol Assessment Ctr, Beijing, Peoples R China 6.Peking Univ, Hosp 6, Inst Mental Hlth, Beijing, Peoples R China 7.Beijing Univ Chinese Med, Sch Acupuncture Moxibust & Tuina, Beijing, Peoples R China 8.Guangzhou Univ Chinese Med, Affiliated Hosp 1, Guangzhou, Peoples R China 9.Bei Tai Ping Zhuang Community Hlth Serv Ctr, Beijing, Peoples R China 10.Beijing Univ Chinese Med, Dongfang Hosp, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Xin-Jing,Zhao, Bing-Cong,Li, Jing,et al. Serum NLRP3 Inflammasome and BDNF: Potential Biomarkers Differentiating Reactive and Endogenous Depression[J]. FRONTIERS IN PSYCHIATRY,2022,13:8. |
| APA | Yang, Xin-Jing.,Zhao, Bing-Cong.,Li, Jing.,Shi, Chuan.,Song, Yu-Qing.,...&Zhang, Zhang-Jin.(2022).Serum NLRP3 Inflammasome and BDNF: Potential Biomarkers Differentiating Reactive and Endogenous Depression.FRONTIERS IN PSYCHIATRY,13,8. |
| MLA | Yang, Xin-Jing,et al."Serum NLRP3 Inflammasome and BDNF: Potential Biomarkers Differentiating Reactive and Endogenous Depression".FRONTIERS IN PSYCHIATRY 13(2022):8. |
入库方式： OAI收割
来源：心理研究所
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