Brain structural abnormalities in adult major depressive disorder revealed by voxel- and source-based morphometry: evidence from the REST-meta-MDD Consortium
文献类型:期刊论文
作者 | Wang, KangCheng1; Hu, YuFei1; Yan, ChaoGan2,3,4,5; Li, MeiLing6; Wu, YanJing7; Qiu, Jiang8; Zhu, XingXing9 |
刊名 | PSYCHOLOGICAL MEDICINE |
出版日期 | 2022-02-15 |
页码 | 11 |
通讯作者邮箱 | qiuj318@swu.edu.cn (jiang qiu) ; x.zhu.4@research.gla.ac.uk (xingxing zhu) |
ISSN号 | 0033-2917 |
关键词 | Brain structure major depressive disorder source-based morphometry structural covariance network voxel-based morphometry |
DOI | 10.1017/S0033291722000320 |
产权排序 | 2 |
文献子类 | 实证研究 |
英文摘要 | Background Neuroimaging studies on major depressive disorder (MDD) have identified an extensive range of brain structural abnormalities, but the exact neural mechanisms associated with MDD remain elusive. Most previous studies were performed with voxel- or surface-based morphometry which were univariate methods without considering spatial information across voxels/vertices. Methods Brain morphology was investigated using voxel-based morphometry (VBM) and source-based morphometry (SBM) in 1082 MDD patients and 990 healthy controls (HCs) from the REST-meta-MDD Consortium. We first examined group differences in regional grey matter (GM) volumes and structural covariance networks between patients and HCs. We then compared first-episode, drug-naive (FEDN) patients, and recurrent patients. Additionally, we assessed the effects of symptom severity and illness duration on brain alterations. Results VBM showed decreased GM volume in various regions in MDD patients including the superior temporal cortex, anterior and middle cingulate cortex, inferior frontal cortex, and precuneus. SBM returned differences only in the prefrontal network. Comparisons between FEDN and recurrent MDD patients showed no significant differences by VBM, but SBM showed greater decreases in prefrontal, basal ganglia, visual, and cerebellar networks in the recurrent group. Moreover, depression severity was associated with volumes in the inferior frontal gyrus and precuneus, as well as the prefrontal network. Conclusions Simultaneous application of VBM and SBM methods revealed brain alterations in MDD patients and specified differences between recurrent and FEDN patients, which tentatively provide an effective multivariate method to identify potential neurobiological markers for depression. |
收录类别 | SCI |
WOS关键词 | GRAY-MATTER ; ORBITOFRONTAL CORTEX ; PREFRONTAL CORTEX ; BASAL GANGLIA ; NETWORK ; COVARIANCE ; INFORMATION ; CEREBELLUM ; RECURRENCE ; MECHANISMS |
资助项目 | National Natural Science Foundation of China[32000760] ; China Postdoctoral Science Foundation[2019M662433] ; Postdoctoral Innovation Project in Shandong Province[239735] ; National Social Science Foundation of China[21AYY014] ; Fundamental Research Funds for the Provincial Universities of Zhejiang ; China Scholarship Council |
WOS研究方向 | Psychology ; Psychiatry |
语种 | 英语 |
出版者 | CAMBRIDGE UNIV PRESS |
WOS记录号 | WOS:000755383600001 |
资助机构 | National Natural Science Foundation of China ; China Postdoctoral Science Foundation ; Postdoctoral Innovation Project in Shandong Province ; National Social Science Foundation of China ; Fundamental Research Funds for the Provincial Universities of Zhejiang ; China Scholarship Council |
源URL | [http://ir.psych.ac.cn/handle/311026/41988] |
专题 | 心理研究所_中国科学院行为科学重点实验室 |
通讯作者 | Qiu, Jiang; Zhu, XingXing |
作者单位 | 1.Shandong Normal Univ, Sch Psychol, Jinan, Shandong, Peoples R China 2.Inst Psychol, CAS Key Lab Behav Sci, Beijing, Peoples R China 3.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 4.Chinese Acad Sci, Magnet Resonance Imaging Res Ctr, Inst Psychol, Beijing, Peoples R China 5.Chinese Acad Sci, Int Big Data Ctr Depress Res, Inst Psychol, Beijing, Peoples R China 6.Harvard Med Sch, Athinoula A Martinos Ctr Biomed Imaging, Massachusetts Gen Hosp, Dept Radiol, Charlestown, MA 02129 USA 7.Ningbo Univ, Fac Foreign Languages, Ningbo, Zhejiang, Peoples R China 8.Southwest Univ, Fac Psychol, Chongqing 400716, Peoples R China 9.Univ Glasgow, Inst Hlth & Wellbeing, Glasgow, Lanark, Scotland |
推荐引用方式 GB/T 7714 | Wang, KangCheng,Hu, YuFei,Yan, ChaoGan,et al. Brain structural abnormalities in adult major depressive disorder revealed by voxel- and source-based morphometry: evidence from the REST-meta-MDD Consortium[J]. PSYCHOLOGICAL MEDICINE,2022:11. |
APA | Wang, KangCheng.,Hu, YuFei.,Yan, ChaoGan.,Li, MeiLing.,Wu, YanJing.,...&Zhu, XingXing.(2022).Brain structural abnormalities in adult major depressive disorder revealed by voxel- and source-based morphometry: evidence from the REST-meta-MDD Consortium.PSYCHOLOGICAL MEDICINE,11. |
MLA | Wang, KangCheng,et al."Brain structural abnormalities in adult major depressive disorder revealed by voxel- and source-based morphometry: evidence from the REST-meta-MDD Consortium".PSYCHOLOGICAL MEDICINE (2022):11. |
入库方式: OAI收割
来源:心理研究所
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