中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Brain structural abnormalities in adult major depressive disorder revealed by voxel- and source-based morphometry: evidence from the REST-meta-MDD Consortium

文献类型:期刊论文

作者Wang, KangCheng1; Hu, YuFei1; Yan, ChaoGan2,3,4,5; Li, MeiLing6; Wu, YanJing7; Qiu, Jiang8; Zhu, XingXing9
刊名PSYCHOLOGICAL MEDICINE
出版日期2022-02-15
页码11
通讯作者邮箱qiuj318@swu.edu.cn (jiang qiu) ; x.zhu.4@research.gla.ac.uk (xingxing zhu)
ISSN号0033-2917
关键词Brain structure major depressive disorder source-based morphometry structural covariance network voxel-based morphometry
DOI10.1017/S0033291722000320
产权排序2
文献子类实证研究
英文摘要

Background Neuroimaging studies on major depressive disorder (MDD) have identified an extensive range of brain structural abnormalities, but the exact neural mechanisms associated with MDD remain elusive. Most previous studies were performed with voxel- or surface-based morphometry which were univariate methods without considering spatial information across voxels/vertices. Methods Brain morphology was investigated using voxel-based morphometry (VBM) and source-based morphometry (SBM) in 1082 MDD patients and 990 healthy controls (HCs) from the REST-meta-MDD Consortium. We first examined group differences in regional grey matter (GM) volumes and structural covariance networks between patients and HCs. We then compared first-episode, drug-naive (FEDN) patients, and recurrent patients. Additionally, we assessed the effects of symptom severity and illness duration on brain alterations. Results VBM showed decreased GM volume in various regions in MDD patients including the superior temporal cortex, anterior and middle cingulate cortex, inferior frontal cortex, and precuneus. SBM returned differences only in the prefrontal network. Comparisons between FEDN and recurrent MDD patients showed no significant differences by VBM, but SBM showed greater decreases in prefrontal, basal ganglia, visual, and cerebellar networks in the recurrent group. Moreover, depression severity was associated with volumes in the inferior frontal gyrus and precuneus, as well as the prefrontal network. Conclusions Simultaneous application of VBM and SBM methods revealed brain alterations in MDD patients and specified differences between recurrent and FEDN patients, which tentatively provide an effective multivariate method to identify potential neurobiological markers for depression.

收录类别SCI
WOS关键词GRAY-MATTER ; ORBITOFRONTAL CORTEX ; PREFRONTAL CORTEX ; BASAL GANGLIA ; NETWORK ; COVARIANCE ; INFORMATION ; CEREBELLUM ; RECURRENCE ; MECHANISMS
资助项目National Natural Science Foundation of China[32000760] ; China Postdoctoral Science Foundation[2019M662433] ; Postdoctoral Innovation Project in Shandong Province[239735] ; National Social Science Foundation of China[21AYY014] ; Fundamental Research Funds for the Provincial Universities of Zhejiang ; China Scholarship Council
WOS研究方向Psychology ; Psychiatry
语种英语
出版者CAMBRIDGE UNIV PRESS
WOS记录号WOS:000755383600001
资助机构National Natural Science Foundation of China ; China Postdoctoral Science Foundation ; Postdoctoral Innovation Project in Shandong Province ; National Social Science Foundation of China ; Fundamental Research Funds for the Provincial Universities of Zhejiang ; China Scholarship Council
源URL[http://ir.psych.ac.cn/handle/311026/41988]  
专题心理研究所_中国科学院行为科学重点实验室
通讯作者Qiu, Jiang; Zhu, XingXing
作者单位1.Shandong Normal Univ, Sch Psychol, Jinan, Shandong, Peoples R China
2.Inst Psychol, CAS Key Lab Behav Sci, Beijing, Peoples R China
3.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
4.Chinese Acad Sci, Magnet Resonance Imaging Res Ctr, Inst Psychol, Beijing, Peoples R China
5.Chinese Acad Sci, Int Big Data Ctr Depress Res, Inst Psychol, Beijing, Peoples R China
6.Harvard Med Sch, Athinoula A Martinos Ctr Biomed Imaging, Massachusetts Gen Hosp, Dept Radiol, Charlestown, MA 02129 USA
7.Ningbo Univ, Fac Foreign Languages, Ningbo, Zhejiang, Peoples R China
8.Southwest Univ, Fac Psychol, Chongqing 400716, Peoples R China
9.Univ Glasgow, Inst Hlth & Wellbeing, Glasgow, Lanark, Scotland
推荐引用方式
GB/T 7714
Wang, KangCheng,Hu, YuFei,Yan, ChaoGan,et al. Brain structural abnormalities in adult major depressive disorder revealed by voxel- and source-based morphometry: evidence from the REST-meta-MDD Consortium[J]. PSYCHOLOGICAL MEDICINE,2022:11.
APA Wang, KangCheng.,Hu, YuFei.,Yan, ChaoGan.,Li, MeiLing.,Wu, YanJing.,...&Zhu, XingXing.(2022).Brain structural abnormalities in adult major depressive disorder revealed by voxel- and source-based morphometry: evidence from the REST-meta-MDD Consortium.PSYCHOLOGICAL MEDICINE,11.
MLA Wang, KangCheng,et al."Brain structural abnormalities in adult major depressive disorder revealed by voxel- and source-based morphometry: evidence from the REST-meta-MDD Consortium".PSYCHOLOGICAL MEDICINE (2022):11.

入库方式: OAI收割

来源:心理研究所

浏览0
下载0
收藏0
其他版本

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。