Antimetastatic effects of Citrus-derived bioactive ingredients: Mechanistic insights
文献类型：期刊论文
| 作者 | Farooqi, Ammad Ahmad6; Tahir, Fatima; Fakhar, Maham2; Butt, Ghazala2; Pimentel, Tatiana Colombo5; Wu, Ning4; Yulaevna, Ishmuratova Margarita3; Attar, Rukset1 |
| 刊名 | CELLULAR AND MOLECULAR BIOLOGY
 |
| 出版日期 | 2021 |
| 卷号 | 67期号:2页码:178-186 |
| 关键词 | Cancer Apoptosis Signaling Xenografted mice |
| ISSN号 | 0145-5680 |
| DOI | 10.14715/cmb/2021.67.2.28 |
| 通讯作者 | Farooqi, Ammad Ahmad(Farooqiammadahmad@gmail.com) ; Butt, Ghazala(dr.ghazalayasmeen@gcu.edu.pk) |
| 英文摘要 | The growing complexity of metastasis has sparked tremendous interest in unraveling of the underlying mechanisms which play fundamental role in cancer progression and metastasis. Ground-breaking discoveries in metastasis research have greatly enhanced our understanding about intricate nature of metastasis. Bioactive chemicals obtained from citrus fruits have gained noteworthy appreciation because of significant cancer chemopreventive roles. Deregulated oncogenic signaling cascades play central role in metastasis. Emerging evidence has started to shed light on the metastasis inhibitory properties of naringin, naringenin, tangeretin, nobiletin, hesperidin and hesperetin in different cancer cell lines and xenografted mice. Wnt/13-catenin, TGF/SMAD and NOTCH signaling cascades have been shown to play linchpin role in carcinogenesis and metastasis. There is emerging evidence related to pharmacological targeting of Wnt/13-catenin, TGF/ SMAD and NOTCH by citrus-derived bioactive components. These findings are indeed encouraging and will enable researchers to gain further insights into pharmacological targeting of oncogenic pathways to inhibit and prevent metastasis. |
| WOS研究方向 | Biochemistry & Molecular Biology ; Cell Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000744172400028 |
| 出版者 | C M B ASSOC |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/177929]  |
| 专题 | 海洋研究所_实验海洋生物学重点实验室 |
| 通讯作者 | Farooqi, Ammad Ahmad; Butt, Ghazala |
| 作者单位 | 1.Yeditepe Univ, Dept Obstet & Gynecol, Istanbul, Turkey 2.Govt Coll Univ, Dept Bot, Lahore, Pakistan 3.EA Buketov Karaganda Univ, Karaganda, Kazakhstan 4.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, CAS & Shandong Prov Key Lab Expt Marine Biol, Qingdao, Peoples R China 5.Fed Inst Parana IFPR, Campus Paranavai, BR-87703536 Paranaque, Brazil 6.Inst Biomed & Genet Engn IBGE, Dept Mol Oncol, Islamabad, Pakistan |
| 推荐引用方式 GB/T 7714 | Farooqi, Ammad Ahmad,Tahir, Fatima,Fakhar, Maham,et al. Antimetastatic effects of Citrus-derived bioactive ingredients: Mechanistic insights[J]. CELLULAR AND MOLECULAR BIOLOGY,2021,67(2):178-186. |
| APA | Farooqi, Ammad Ahmad.,Tahir, Fatima.,Fakhar, Maham.,Butt, Ghazala.,Pimentel, Tatiana Colombo.,...&Attar, Rukset.(2021).Antimetastatic effects of Citrus-derived bioactive ingredients: Mechanistic insights.CELLULAR AND MOLECULAR BIOLOGY,67(2),178-186. |
| MLA | Farooqi, Ammad Ahmad,et al."Antimetastatic effects of Citrus-derived bioactive ingredients: Mechanistic insights".CELLULAR AND MOLECULAR BIOLOGY 67.2(2021):178-186. |
入库方式： OAI收割
来源：海洋研究所
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