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Transcriptomic Response to Perkinsus marinus in Two Crassostrea Oysters Reveals Evolutionary Dynamics of Host-Parasite Interactions

文献类型：期刊论文

作者Chan, Jiulin1,2,5,6; Wang, Lu1,2,3,5,6; Li, Li1,2,3,5,6; Mu, Kang1,2,3,5,6; Bushek, David4; Xu, Yue1,2,5,6; Guo, Ximing4; Zhang, Guofan1,2,3,5,6; Zhang, Linlin1,2,3,5,6
刊名FRONTIERS IN GENETICS
出版日期2021-12-03
卷号12页码:16
关键词oyster comparative transcriptomics dermo disease innate immune response host-parasite interaction gene expansion adaptation
DOI10.3389/fgene.2021.795706
通讯作者Guo, Ximing(xguo@hsrl.rutgers.edu) ; Zhang, Guofan(gfzhang@qdio.ac.cn) ; Zhang, Linlin(linlinzhang@qdio.ac.cn)
英文摘要Infectious disease outbreaks are causing widespread declines of marine invertebrates including corals, sea stars, shrimps, and molluscs. Dermo is a lethal infectious disease of the eastern oyster Crassostrea virginica caused by the protist Perkinsus marinus. The Pacific oyster Crassostrea gigas is resistant to Dermo due to differences in the host-parasite interaction that is not well understood. We compared transcriptomic responses to P. marinus challenge in the two oysters at early and late infection stages. Dynamic and orchestrated regulation of large sets of innate immune response genes were observed in both species with remarkably similar patterns for most orthologs, although responses in C. virginica were stronger, suggesting strong or over-reacting immune response could be a cause of host mortality. Between the two species, several key immune response gene families differed in their expansion, sequence variation and/or transcriptional response to P. marinus, reflecting evolutionary divergence in host-parasite interaction. Of note, significant upregulation of inhibitors of apoptosis (IAPs) was observed in resistant C. gigas but not in susceptible C. virginica, suggesting upregulation of IAPs is an active defense mechanism, not a passive response orchestrated by P. marinus. Compared with C. gigas, C. virginica exhibited greater expansion of toll-like receptors (TLRs) and positive selection in P. marinus responsive TLRs. The C1q domain containing proteins (C1qDCs) with the galactose-binding lectin domain that is involved in P. marinus recognition, were only present and significantly upregulated in C. virginica. These results point to previously undescribed differences in host defense genes between the two oyster species that may account for the difference in susceptibility, providing an expanded portrait of the evolutionary dynamics of host-parasite interaction in lophotrochozoans that lack adaptive immunity. Our findings suggest that C. virginica and P. marinus have a history of coevolution and the recent outbreaks may be due to increased virulence of the parasite.
资助项目Priority Research Program of the Chinese Academy of Sciences[XDB42000000] ; National Natural Science Foundation of China[41976088] ; Key Development Project of Centre for Ocean Mega-Research of Science, Chinese academy of science[COMS2019R01] ; USDA NIFA Hatch project[1009201-NJ32114] ; USDA NIFA Hatch/Animal Health project[1004475-NJ32920]
WOS研究方向Genetics & Heredity
语种英语
WOS记录号WOS:000761070300001
出版者FRONTIERS MEDIA SA
源URL[http://ir.qdio.ac.cn/handle/337002/178062]  
专题海洋研究所_实验海洋生物学重点实验室
通讯作者Guo, Ximing; Zhang, Guofan; Zhang, Linlin
作者单位1.Chinese Acad Sci, Ctr Ocean Mega Sci, Inst Oceanol, Shandong Prov Key Lab Expt Marine Biol, Qingdao, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China
3.Univ Chinese Acad Sci, Coll Marine Sci, Beijing, Peoples R China
4.Rutgers State Univ, Dept Marine & Coastal Sci, Haskin Shellfish Res Lab, Port Norris, NJ 08349 USA
5.Chinese Acad Sci, Qingdao, Peoples R China
6.Chinese Acad Sci, Ctr Ocean Mega Sci, Inst Oceanol, Ctr Deep Sea Res, Qingdao, Peoples R China
推荐引用方式
GB/T 7714		 Chan, Jiulin,Wang, Lu,Li, Li,et al. Transcriptomic Response to Perkinsus marinus in Two Crassostrea Oysters Reveals Evolutionary Dynamics of Host-Parasite Interactions[J]. FRONTIERS IN GENETICS,2021,12:16.
APA Chan, Jiulin.,Wang, Lu.,Li, Li.,Mu, Kang.,Bushek, David.,...&Zhang, Linlin.(2021).Transcriptomic Response to Perkinsus marinus in Two Crassostrea Oysters Reveals Evolutionary Dynamics of Host-Parasite Interactions.FRONTIERS IN GENETICS,12,16.
MLA Chan, Jiulin,et al."Transcriptomic Response to Perkinsus marinus in Two Crassostrea Oysters Reveals Evolutionary Dynamics of Host-Parasite Interactions".FRONTIERS IN GENETICS 12(2021):16.

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来源：海洋研究所

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