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Selective ATP Detection via Activation of MoS2-Based Artificial Nanozymes Inhibited by ZIF-90 Nanoparticles

文献类型：期刊论文

作者Wang, Yingwen1,2,3; Zhang, Dun1,2,3; Zeng, Yan2,3; Qi, Peng1,2,3
刊名ACS APPLIED NANO MATERIALS
出版日期2021-11-26
卷号4期号:11页码:11545-11553
关键词ZIF-90 nanoparticles MoS2 nanozyme inhibitory effect discriminative ATP detection optical and electrochemical modes
DOI10.1021/acsanm.1c01986
通讯作者Zhang, Dun(zhangdun@qdio.ac.cn) ; Qi, Peng(qipeng@qdio.ac.cn)
英文摘要In this paper, we presented an ATP detection platform based on the selective activation of an artificial nanozyme inhibited by ZIF-90 nanoparticles. For the first time, we found and reported the inhibitory effect of ZIF-90 nanoparticles on the MoS2 nanozyme, and this property was integrated with its ATP-responsive ability to develop an ATP detection biosensor. The presence of ATP triggers the decomposition of ZIF-90, thus eliminating the inhibition ability and recovering the catalytic ability of the MoS2 nanozyme. By measuring the catalytic activity in the H2O2 -TMB reaction system with optical and electrochemical methods, the ATP detection performance was evaluated systematically. The proposed detection method exhibited excellent sensitivity and selectivity, and the optical and electrochemical modes satisfied the requirements of different application circumstances. In addition, taking advantage of the mild and rapid bacterial disintegration properties of antibiotic peptide-modified magnetic nanoparticles (M-AMPs), using the proposed platform based on selective activation of ZIF-90 nanoparticles inhibited the MoS2 nanozyme, discriminative ATP detection was performed. This work confirms that the inhibitory effect of ZIF-90 nanoparticles on the MoS2 artificial nanozyme provides an idea for developing biosensing systems based on enzyme inhibition and, more importantly, holds great potential for expanding the application of ZIF-90 nanoparticles in analytical fields.
资助项目National Natural Science Foundation of China[41876101] ; National Natural Science Foundation of China[41906037] ; Nantong Scientific Plan Foundation[JC2021054] ; Nantong Scientific Plan Foundation[2020NT04]
WOS研究方向Science & Technology - Other Topics ; Materials Science
语种英语
WOS记录号WOS:000752894100015
出版者AMER CHEMICAL SOC
源URL[http://ir.qdio.ac.cn/handle/337002/177993]  
专题海洋研究所_海洋腐蚀与防护研究发展中心
通讯作者Zhang, Dun; Qi, Peng
作者单位1.Univ Chinese Acad Sci, Beijing 100039, Peoples R China
2.Pilot Natl Lab Marine Sci & Technol Qingdao, Open Studio Marine Corros & Protect, Qingdao 266237, Shandong, Peoples R China
3.Chinese Acad Sci, Key Lab Marine Environm Corros & Biofouling, Inst Oceanol, Qingdao 266071, Peoples R China
推荐引用方式
GB/T 7714		 Wang, Yingwen,Zhang, Dun,Zeng, Yan,et al. Selective ATP Detection via Activation of MoS2-Based Artificial Nanozymes Inhibited by ZIF-90 Nanoparticles[J]. ACS APPLIED NANO MATERIALS,2021,4(11):11545-11553.
APA Wang, Yingwen,Zhang, Dun,Zeng, Yan,&Qi, Peng.(2021).Selective ATP Detection via Activation of MoS2-Based Artificial Nanozymes Inhibited by ZIF-90 Nanoparticles.ACS APPLIED NANO MATERIALS,4(11),11545-11553.
MLA Wang, Yingwen,et al."Selective ATP Detection via Activation of MoS2-Based Artificial Nanozymes Inhibited by ZIF-90 Nanoparticles".ACS APPLIED NANO MATERIALS 4.11(2021):11545-11553.

入库方式： OAI收割

来源：海洋研究所

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