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Article The cell-surface 5 '-nucleotidase CD73 defines a functional T memory cell subset that declines with age

文献类型：期刊论文

作者Fang, Fengqin1,2; Cao, Wenqiang1,2,3; Zhu, Weikang4,5; Lam, Nora6,7; Li, Lingjie8,9,10; Gaddam, Sadhana8,9; Wang, Yong4,5; Kim, Chulwoo1,2; Lambert, Simon1,2; Zhang, Huimin1,2,3
刊名CELL REPORTS
出版日期2021-11-09
卷号37期号:6页码:24
ISSN号2211-1247
DOI10.1016/j.celrep.2021.109981
英文摘要Memory T cells exhibit considerable diversity that determines their ability to be protective. Here, we examine whether changes in T cell heterogeneity contribute to the age-associated failure of immune memory. By screening for age-dependent T cell-surface markers, we identify CD4 and CD8 memory T cell subsets that are unrelated to previously defined subsets of central and effector memory cells. Memory T cells expressing the ecto-5'-nucleotidase CD73 constitute a functionally distinct subset of memory T cells that declines with age. They resemble long-lived, polyfunctional memory cells but are also poised to display effector functions and to develop into cells resembling tissue-resident memory T cells (TRMs). Upstream regulators of differential chromatin accessibility and transcriptomes include transcription factors that facilitate CD73 expression and regulate TRM differentiation. CD73 is not just a surrogate marker of these regulatory networks but is directly involved in T cell survival.
资助项目National Institutes of Health[R01 AR042527] ; National Institutes of Health[R01 HL117913] ; National Institutes of Health[R01 AI108906] ; National Institutes of Health[R01 HL142068] ; National Institutes of Health[P01 HL129941] ; National Institutes of Health[P01 AI106697] ; National Institutes of Health[R01 AI108891] ; National Institutes of Health[R01 AG045779] ; National Institutes of Health[U19 AI057266] ; National Institutes of Health[R01 AI129191] ; National Natural Science Foundation of China (NSFC)[11871463] ; National Natural Science Foundation of China (NSFC)[12025107] ; National Natural Science Foundation of China (NSFC)[61621003] ; NSF GRFP ; US Department of Veterans Affairs ; Palo Alto Veterans Institute for Research
WOS研究方向Cell Biology
语种英语
WOS记录号WOS:000718275500005
出版者CELL PRESS
源URL[http://ir.amss.ac.cn/handle/2S8OKBNM/59568]  
专题应用数学研究所
通讯作者Goronzy, Jorg J.
作者单位1.Stanford Univ, Dept Med, Div Immunol & Rheumatol, Stanford, CA 94305 USA
2.Palo Alto Vet Adm Healthcare Syst, Dept Med, Palo Alto, CA 94304 USA
3.Mayo Clin, Coll Med & Sci, Dept Immunol, Rochester, MN 55905 USA
4.Chinese Acad Sci, Acad Math & Syst Sci, MDIS, CEMS,NCMIS,HCMS, Beijing 100190, Peoples R China
5.Chinese Acad Sci, Ctr Excellence Anim Evolut & Genet, Kunming 650223, Yunnan, Peoples R China
6.Columbia Univ, Irving Med Ctr, Dept Pathol & Cell Biol, New York, NY 10032 USA
7.Columbia Univ, Irving Med Ctr, Dept Microbiol & Immunol, New York, NY 10032 USA
8.Stanford Univ, Sch Med, Program Epithelial Biol, Stanford, CA 94305 USA
9.Stanford Univ, Sch Med, Dept Dermatol, Stanford, CA 94305 USA
10.Shanghai Jiao Tong Univ, Sch Med, Dept Histoembryol Genet & Dev Biol, Shanghai Key Lab Reprod Med, Shanghai 200025, Peoples R China
推荐引用方式
GB/T 7714		 Fang, Fengqin,Cao, Wenqiang,Zhu, Weikang,et al. Article The cell-surface 5 '-nucleotidase CD73 defines a functional T memory cell subset that declines with age[J]. CELL REPORTS,2021,37(6):24.
APA Fang, Fengqin.,Cao, Wenqiang.,Zhu, Weikang.,Lam, Nora.,Li, Lingjie.,...&Goronzy, Jorg J..(2021).Article The cell-surface 5 '-nucleotidase CD73 defines a functional T memory cell subset that declines with age.CELL REPORTS,37(6),24.
MLA Fang, Fengqin,et al."Article The cell-surface 5 '-nucleotidase CD73 defines a functional T memory cell subset that declines with age".CELL REPORTS 37.6(2021):24.

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来源：数学与系统科学研究院

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