Host-microbiota interactions and responses to grass carp reovirus infection in Ctenopharyngodon idellus
文献类型：期刊论文
| 作者 | Xiao, Fanshu; Liao, Lanjie; Xu, Qiaoqing; He, Zhili; Xiao, Tiaoyi; Wang, Jianjun; Huang, Jie; Yu, Yuhe; Wu, Bo; Yan, Qingyun |
| 刊名 | ENVIRONMENTAL MICROBIOLOGY
 |
| 出版日期 | 2020 |
| 卷号 | 23期号:1 |
| 英文摘要 | Gut microbiota could facilitate host to defense diseases, but fish-microbiota interactions during viral infection and the underlying mechanism are poorly understood. We examined interactions and responses of gut microbiota to grass carp reovirus (GCRV) infection in Ctenopharyngodon idellus, which is the most important aquaculture fish worldwide. We found that GCRV infection group with serious haemorrhagic symptoms (G7s) showed considerably different gut microbiota, especially with an abnormally high abundance of gram-negative anaerobic Cetobacterium somerae. It also showed the lowest (p < 0.05) alpha-diversity but with much higher ecological process of homogenizing dispersal (28.8%), confirming a dysbiosis of the gut microbiota after viral infection. Interestingly, signaling pathways of NOD-like receptors (NLRs), toll-like receptors (TLRs), and lipopolysaccharide (LPS) stimulation genes were significantly (q-value < 0.01) enriched in G7s, which also significantly (p < 0.01) correlated with the core gut microbial genera of Cetobacterium and Acinetobacter. The results suggested that an expansion of C. somerae initiated by GCRV could aggravate host inflammatory reactions through the LPS-related NLRs and TLRs pathways. This study advances our understanding of the interplay between fish immunity and gut microbiota challenged by viruses; it also sheds new insights for ecological defense of fish diseases with the help of gut microbiota. |
| 源URL | [http://159.226.73.51/handle/332005/20221]  |
| 专题 | 中国科学院南京地理与湖泊研究所 |
| 推荐引用方式 GB/T 7714 | Xiao, Fanshu,Liao, Lanjie,Xu, Qiaoqing,et al. Host-microbiota interactions and responses to grass carp reovirus infection in Ctenopharyngodon idellus[J]. ENVIRONMENTAL MICROBIOLOGY,2020,23(1). |
| APA | Xiao, Fanshu.,Liao, Lanjie.,Xu, Qiaoqing.,He, Zhili.,Xiao, Tiaoyi.,...&Yan, Qingyun.(2020).Host-microbiota interactions and responses to grass carp reovirus infection in Ctenopharyngodon idellus.ENVIRONMENTAL MICROBIOLOGY,23(1). |
| MLA | Xiao, Fanshu,et al."Host-microbiota interactions and responses to grass carp reovirus infection in Ctenopharyngodon idellus".ENVIRONMENTAL MICROBIOLOGY 23.1(2020). |
入库方式： OAI收割
来源：南京地理与湖泊研究所
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