Effects of erythromycin and sulfamethoxazole on Microcystis aeruginosa: Cytotoxic endpoints, production and release of microcystin-LR
文献类型：期刊论文
| 作者 | Zhang, Mingchen; Steinman, Alan D.; Xue, Qingju; Zhao, Yanyan; Xu, Yan; Xie, Liqiang |
| 刊名 | JOURNAL OF HAZARDOUS MATERIALS
 |
| 出版日期 | 2020 |
| 卷号 | 399 |
| 英文摘要 | Antibiotics can cause severe ecological problems for aquatic ecosystems due to their wide use and incomplete removal. Microcystis aeruginosa was exposed to different levels of erythromycin (ERY) and sulfamethoxazole (SMX) separately to assess their cytotoxic effects on harmful cyanobacteria. The production and release of the toxin MC-LR was measured, and several endpoints were investigated using flow cytometry (FCM) for 7 d. ERY resulted in cell membrane hyperpolarization and a hormesis effect on growth rate and chlorophyll a fluorescence at environmentally relevant concentrations (0.5 and 5 mu g/L). Microcystis exhibited elevated photosynthesis and hyperpolarization at 50 and 125 mu g/L of SMX. An increase of metabolically non-active cells was observed in either ERY or SMX cultures while stimulation of esterase activity was also found at 7 d. ERY and SMX caused damage of membrane integrity due to the overproduction of ROS, which led to increased release of MC-LR. MC-LR production apparently was induced by ERY (0.5-500 mu g/L) and SMX (50 and 125 mu g/L). In conclusion, ERY and SMX can disrupt the physiological status of Microcystis cells and stimulate the production and release of MC-LR, which can exacerbate potential risks to water systems. |
| 源URL | [http://159.226.73.51/handle/332005/20246]  |
| 专题 | 中国科学院南京地理与湖泊研究所 |
| 推荐引用方式 GB/T 7714 | Zhang, Mingchen,Steinman, Alan D.,Xue, Qingju,et al. Effects of erythromycin and sulfamethoxazole on Microcystis aeruginosa: Cytotoxic endpoints, production and release of microcystin-LR[J]. JOURNAL OF HAZARDOUS MATERIALS,2020,399. |
| APA | Zhang, Mingchen,Steinman, Alan D.,Xue, Qingju,Zhao, Yanyan,Xu, Yan,&Xie, Liqiang.(2020).Effects of erythromycin and sulfamethoxazole on Microcystis aeruginosa: Cytotoxic endpoints, production and release of microcystin-LR.JOURNAL OF HAZARDOUS MATERIALS,399. |
| MLA | Zhang, Mingchen,et al."Effects of erythromycin and sulfamethoxazole on Microcystis aeruginosa: Cytotoxic endpoints, production and release of microcystin-LR".JOURNAL OF HAZARDOUS MATERIALS 399(2020). |
入库方式： OAI收割
来源：南京地理与湖泊研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。