Modeling study of adsorption/desorption of proteins by polymer mixed brush
文献类型：期刊论文
| 作者 | Liu Chun-Jie3; Zhao Xin-Jun2,3; Gao Zhi-Fu1 ; Jiang Zhong-Ying2
|
| 刊名 | ACTA PHYSICA SINICA
 |
| 出版日期 | 2021-11-20 |
| 卷号 | 70期号:22页码:10 |
| 关键词 | polymer mixed brush protein adsorption/desorption dynamic properties |
| ISSN号 | 1000-3290 |
| DOI | 10.7498/aps.70.20211219 |
| 通讯作者 | Zhao Xin-Jun(zhaoxinjunzxj@163.com) |
| 英文摘要 | Based on the diffusion dynamics, a new theoretical model is established to investigate the dynamic properties of a polymer mixed brush (PMB) in the protein adsorption/desorption process. The theoretical model considers the adsorption of proteins by one polymer chain (P-polymer chain) and the desorption of proteins by another polymer chain (N-polymer chain) in a PMB, as well as the time delay between adsorption and desorption. The dynamic properties of protein adsorption/desorption by a PMB depend on not only the chemical and physical properties of polymer chains, but also the microenvironment (density of protein in the solution and protein diffusivity) of the PMB. In order to describe the different chemical and physical properties of polymer chains and microenvironments in PMB, we take different model parameters, and obtain partial adsorption/desorption, complete adsorption/desorption and periodic adsorption/desorption of proteins by the PMB. By analyzing the process of protein adsorption/desorption in a PMB, we find that the microenvironment has an obvious influence on the adsorption and desorption of protein by the PMB. It is also shown that the adsorption of protein and the desorption of protein by the PMB have a stable and invariable periodic cycle when an alternating electric field is applied. The average adsorption capacity and the average desorption capacity increase in comparison with those when no electric field is applied. A stable alternating electric field enables the PMB to exhibit stable periodic dynamic characteristics in the dynamic process of protein adsorption and desorption. Our theoretical results are consistent with the experimental observations. Based on this, it is predicted that an external electric field can realize multiple cycles of protein adsorption and desorption by PMB, which provides necessary references and useful insights into controllable protein adsorption/desorption by the PMB in the practical applications. |
| WOS关键词 | SERUM-ALBUMIN ; ADSORPTION ; SURFACES ; KINETICS ; DENSITY ; DESIGN ; LAYERS |
| 资助项目 | National Natural Science Foundation of China[22163011] ; Yi Li Normal University Doctoral Research Startup Foundation, China[2020YSBS008] ; Joint Funds of Xinjiang Natural Science Foundation, China[2019D01C333] |
| WOS研究方向 | Physics |
| 语种 | 英语 |
| WOS记录号 | WOS:000732827600023 |
| 出版者 | CHINESE PHYSICAL SOC |
| 资助机构 | National Natural Science Foundation of China ; Yi Li Normal University Doctoral Research Startup Foundation, China ; Joint Funds of Xinjiang Natural Science Foundation, China |
| 源URL | [http://ir.xao.ac.cn/handle/45760611-7/4414]  |
| 专题 | 脉冲星研究团组 |
| 通讯作者 | Zhao Xin-Jun |
| 作者单位 | 1.Chinese Acad Sci, Xinjiang Astron Observ, Urumqi 830011, Peoples R China 2.Yi Li Normal Univ, Lab Micronano Elect Biosensors & Bion Devices, Yining 835000, Peoples R China 3.Yi Li Normal Univ, Xinjiang Lab Phase Transit & Microstruct Condence, Yining 835000, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu Chun-Jie,Zhao Xin-Jun,Gao Zhi-Fu,et al. Modeling study of adsorption/desorption of proteins by polymer mixed brush[J]. ACTA PHYSICA SINICA,2021,70(22):10. |
| APA | Liu Chun-Jie,Zhao Xin-Jun,Gao Zhi-Fu,&Jiang Zhong-Ying.(2021).Modeling study of adsorption/desorption of proteins by polymer mixed brush.ACTA PHYSICA SINICA,70(22),10. |
| MLA | Liu Chun-Jie,et al."Modeling study of adsorption/desorption of proteins by polymer mixed brush".ACTA PHYSICA SINICA 70.22(2021):10. |
入库方式： OAI收割
来源：新疆天文台
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。