均一、稳定的碘油复乳药物载体的制备
文献类型：学位论文
| 作者 | 邵辉 |
| 学位类别 | 硕士 |
| 答辩日期 | 2003 |
| 授予单位 | 中国科学院过程工程研究所 |
| 授予地点 | 中国科学院过程工程研究所 |
| 导师 | 马光辉 |
| 关键词 | 微孔膜乳化 碘油 W/O/W型复乳 体外释药 |
| 其他题名 | Preparation of Lipiodol Double Emulsion as Drug Carrier by Microporous Membrane Emulsification Technique |
| 学位专业 | 生物化工 |
| 中文摘要 | 该论文针对临床上用于肝动脉栓塞治疗的抗癌剂碘油复乳载体存在的粒径分布宽、包埋率低、稳定性差的问题,总结以往乳化技术经验,采用新型的维孔膜乳化技术(microporous membrane emulsification technique),制备了尺寸均一的、稳定的抗癌剂碘油复乳载体.该论文分别对丝裂酶素C、阿酶素两种不同的抗癌剂进行包埋,通过对制备的抗癌剂碘油复乳载体的粒径分布、药物包埋率、体外释药性等进行研究,优化了复乳载体的制备条件,并确定了最佳配方,得到了粒径分布窄、包埋率高、稳定性好的复乳载体.最后,该论文探讨了内水相添加剂及油相添加剂对复乳药物载体稳定性的影响. |
| 英文摘要 | Drug carrier is very important for realizing drug's targeting, improving the half life time, and reducing the side effects of drugs. In order to solve the problem of unstability and low encapsulation efficiency in current Lipiodol double emulsion for liver artery injection chemotherapy, a novei microporous membrane emulsification technique was introduced to prepare water-in-oil-in-water Lipiodol double emulsion with uniform size and high encapsulation efficiency, as drug carrier. In this thesis, Mitomycin C and Adromycin were used as model drugs, and the effects of preparative conditions on size distribution of double emulsion, encapsulation efficiency, and release behavior in vitro were investigated. Fairly stable double emulsion with uniform size and high encapsulation efficiency was obtained by optimizing the formulation of Lipiodol double emulsion. The size distribution was lower than 15%, encapsulation efficiency was high up to 90%, and shelf stability at 4°C attained to 30 days with lower than 10% of drug released, and the drug can be released steadily at 37°C. Different sized Lipiodol double emulsion entrapped ADM were prepared, using different microporous membrane with different pores. It was observed that the drop size of emulsion is related to the pore size of membrane by a linear relationship. The effect of size of double emulsion on the encapsulation efficiency and release behavior in vitro were also discussed. In order to meet clinical need, Lipiodol double emulsion with different ADM dosage entrapped was prepared. In order to improve the stability of Lipiodol double emulsion further, the effects of additives in inner phase and oil phase on the stability of Lipiodol double emulsion were investigated. It is found that the addictions of BSA macromolecules in inner water phase enhanced the mechanical strength of the film between Lipiodol and inner water phase, which improved the encapsulation efficiency and the stability of Lipiodol double emulsion. By adding Cholesterol and L-a-Phosphatidylcholine together into the oil phase, a structure like liposome was probably formed, which also improved the encapsulation efficiency and the stability of Lipiodol double emulsion. It can be concluded that the Lipiodol double emulsion entrapped anticancer drugs with narrow size distribution, high encapsulation efficiency and long term shelf-stability can be prepared by the microporous membrane emulsification technique. It can be expected that the targeting of the canier can be improved and the side-effect can be reduced further. |
| 语种 | 中文 |
| 公开日期 | 2013-09-16 |
| 页码 | 80 |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/1362]  |
| 专题 | 过程工程研究所_研究所（批量导入） |
| 推荐引用方式 GB/T 7714 | 邵辉. 均一、稳定的碘油复乳药物载体的制备[D]. 中国科学院过程工程研究所. 中国科学院过程工程研究所. 2003. |
入库方式： OAI收割
来源：过程工程研究所
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