Iridium-Catalyzed Enantioselective Unbiased Methylene C(sp(3))-H Borylation of Acyclic Amides
文献类型：期刊论文
| 作者 | Yang, Yuhuan2,3; Chen, Lili3; Xu, Senmiao1,3
|
| 刊名 | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
 |
| 出版日期 | 2020-12-14 |
| 页码 | 6 |
| 关键词 | asymmetric catalysis C− H activation iridium organoboron synthetic methods |
| ISSN号 | 1433-7851 |
| DOI | 10.1002/anie.202013568 |
| 通讯作者 | Xu, Senmiao(senmiaoxu@licp.cas.cn) |
| 英文摘要 | We herein report amide directed enantioselective beta-C(sp(3))-H borylation of unbiased methylene C-H bonds of acyclic amides enabled by iridium catalysis for the first time. The key to the success of this transformation relies on the careful selection of the combination of iridium precursor and chiral bidentate boryl ligands. A variety of functional groups are well-tolerated, affording chiral beta-functionalized amides in good to excellent enantioselectivities. We also demonstrate the application of the current method by stereospecific conversion of C-B bond into other functionalities. |
| 资助项目 | National Natural Science Foundation of China[21873261] ; National Natural Science Foundation of China[91956116] ; Natural Science Foundation of Jiangsu Province[BK20170422] ; Hangzhou Normal University ; Lanzhou Institute of Chemical Physics |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 资助机构 | National Natural Science Foundation of China ; Natural Science Foundation of Jiangsu Province ; Hangzhou Normal University ; Lanzhou Institute of Chemical Physics |
| 源URL | [http://ir.licp.cn/handle/362003/28233]  |
| 专题 | 兰州化学物理研究所_OSSO国家重点实验室 |
| 通讯作者 | Xu, Senmiao |
| 作者单位 | 1.Hangzhou Normal Univ, Key Lab Organosilicon Chem & Mat Technol, Minist Educ, Hangzhou 311121, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Oxo Synth & Select Oxidat, Ctr Excellence Mol Synth,Suzhou Res Inst, Lanzhou 730000, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Yuhuan,Chen, Lili,Xu, Senmiao. Iridium-Catalyzed Enantioselective Unbiased Methylene C(sp(3))-H Borylation of Acyclic Amides[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2020:6. |
| APA | Yang, Yuhuan,Chen, Lili,&Xu, Senmiao.(2020).Iridium-Catalyzed Enantioselective Unbiased Methylene C(sp(3))-H Borylation of Acyclic Amides.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,6. |
| MLA | Yang, Yuhuan,et al."Iridium-Catalyzed Enantioselective Unbiased Methylene C(sp(3))-H Borylation of Acyclic Amides".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020):6. |
入库方式： OAI收割
来源：兰州化学物理研究所
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