Recent Advances in the Synthesis of CF3- or HCF2-Substituted Cyclopropanes
文献类型：期刊论文
| 作者 | Wu, Wen-Feng; Lin, Jin-Hong; Xiao, Ji-Chang; Cao, Yu-Cai; Ma, Yanfang
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| 刊名 | ASIAN JOURNAL OF ORGANIC CHEMISTRY
 |
| 出版日期 | 2021-03 |
| 卷号 | 10期号:3页码:485-495 |
| ISSN号 | 2193-5807 |
| DOI | 10.1002/ajoc.202000723 |
| 英文摘要 | CF3- or HCF2-substituted cyclopropanes are of great interest in pharmaceutical chemistry and agrochemistry, and thus significant efforts have been directed towards the development of efficient methods for the installation of these motifs. This Minireview summarizes recent efforts for the construction of CF3- or HCF2-substituted cyclopropanes. CF3-cyclopropanes are usually synthesized by a transition-metal-catalyzed cyclopropanation of alkenes with a trifluoromethylcarbene generated in situ from a diazocompound, CF3CHN2 or CF3C(Ar)N-2. The synthesis of HCF2-cyclopropanes remains largely unexplored. Some difluoromethylcarbene reagents have been developed, such as HCF2CHN2, Ph2S+CH2CF2H TfO-, and difluoroacetaldehyde N-triftosylhydrazone (DFHZ-Tfs), and cyclopropanation of alkenes with these reagents could also occur by transition metal catalysis. These protocols may find great utility in the synthesis of biologically active molecules. |
| 源URL | [http://ir.isl.ac.cn/handle/363002/34333]  |
| 专题 | 青海盐湖研究所_盐湖资源与化学实验室 |
| 推荐引用方式 GB/T 7714 | Wu, Wen-Feng,Lin, Jin-Hong,Xiao, Ji-Chang,et al. Recent Advances in the Synthesis of CF3- or HCF2-Substituted Cyclopropanes[J]. ASIAN JOURNAL OF ORGANIC CHEMISTRY,2021,10(3):485-495. |
| APA | Wu, Wen-Feng,Lin, Jin-Hong,Xiao, Ji-Chang,Cao, Yu-Cai,&Ma, Yanfang.(2021).Recent Advances in the Synthesis of CF3- or HCF2-Substituted Cyclopropanes.ASIAN JOURNAL OF ORGANIC CHEMISTRY,10(3),485-495. |
| MLA | Wu, Wen-Feng,et al."Recent Advances in the Synthesis of CF3- or HCF2-Substituted Cyclopropanes".ASIAN JOURNAL OF ORGANIC CHEMISTRY 10.3(2021):485-495. |
入库方式： OAI收割
来源：青海盐湖研究所
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