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Gnas Promoter Hypermethylation in the Basolateral Amygdala Regulates Reconsolidation of Morphine Reward Memory in Rats

文献类型：期刊论文

作者Liu, Peng3,4; Liang, Jialong2; Jiang, Fengze3,4; Cai, Wanshi2; Shen, Fang3,4; Liang, Jing3,4; Zhang, Jianjun3,4; Sun, Zhongsheng1,2; Sui, Nan3,4
刊名GENES
出版日期2022-03-01
卷号13期号:3页码:16
关键词DNA methylation DNA methyltransferases morphine basolateral amygdala reconsolidation memory
DOI10.3390/genes13030553
通讯作者Zhang, Jianjun(zhangjj@psych.ac.cn) ; Sun, Zhongsheng(sunzs@mail.biols.ac.cn)
英文摘要Impairing reconsolidation may disrupt drug memories to prevent relapse, meanwhile long-term transcription regulations in the brain regions contribute to the occurrence of emotional memories. The basolateral amygdala (BLA) is involved in the drug-cue association, while the nucleus accumbens (NAc) responds to the drug reward. Here, we assessed whether DNA methyltransferases (Dnmts) in these two brain regions function identically in the reconsolidation of morphine reward memory. We show that Dnmts inhibition in the BLA but not in the NAc after memory retrieval impaired reconsolidation of a morphine reward memory. Moreover, the mRNA levels of Dnmt3a and Dnmt3b, rather than Dnmt1, in the BLA were continuously upregulated after retrieval. We further identified the differentially methylated regions (DMRs) in genes in the BLA after retrieval, and focused on the DMRs located in gene promoter regions. Among them were three genes (Gnas, Sox10, and Pik3r1) involved in memory modulation. Furthermore, Gnas promoter hypermethylation was confirmed to be inversely correlated with the downregulation of Gnas mRNA levels. The findings indicate that the specific transcription regulation mechanism in the BLA and NAc on reconsolidation of opiate-associated memories can be dissociable, and DNA hypermethylation of Gnas in the BLA is necessary for the reconsolidation of morphine reward memories.
收录类别SCI
WOS关键词INDUCED PLACE PREFERENCE ; POST-RETRIEVAL EXTINCTION ; DNA METHYLATION ; NUCLEUS-ACCUMBENS ; PROTEIN-SYNTHESIS ; ACTIVATION ; RECEPTORS ; KINASE ; GENE ; NMDA
资助项目Chinese National Programs for Brain Science and Brain-like Intelligence Technology[2021ZD0202104] ; National Key Research and Development Program of China[2016YFC0900400] ; National Natural Science Foundation of China[31571301] ; National Natural Science Foundation of China[31400880] ; National Natural Science Foundation of China[31871111] ; Youth Innovation Promotion Association CAS[2020088] ; Key Laboratory of Mental Health, Institute of Psychology, CAS
WOS研究方向Genetics & Heredity
语种英语
出版者MDPI
WOS记录号WOS:000775235400001
资助机构Chinese National Programs for Brain Science and Brain-like Intelligence Technology ; National Key Research and Development Program of China ; National Natural Science Foundation of China ; Youth Innovation Promotion Association CAS ; Key Laboratory of Mental Health, Institute of Psychology, CAS
源URL[http://ir.psych.ac.cn/handle/311026/42361]  
专题心理研究所_中国科学院心理健康重点实验室
通讯作者Zhang, Jianjun; Sun, Zhongsheng
作者单位1.Wenzhou Med Univ, Inst Genom Med, Wenzhou 325000, Peoples R China
2.Chinese Acad Sci, Beijing Inst Life Sci, Beijing 100101, Peoples R China
3.Univ Chinese Acad Sci, Dept Psychol, Beijing 100101, Peoples R China
4.Inst Psychol, CAS Key Lab Mental Hlth, Beijing 100101, Peoples R China
推荐引用方式
GB/T 7714		 Liu, Peng,Liang, Jialong,Jiang, Fengze,et al. Gnas Promoter Hypermethylation in the Basolateral Amygdala Regulates Reconsolidation of Morphine Reward Memory in Rats[J]. GENES,2022,13(3):16.
APA Liu, Peng.,Liang, Jialong.,Jiang, Fengze.,Cai, Wanshi.,Shen, Fang.,...&Sui, Nan.(2022).Gnas Promoter Hypermethylation in the Basolateral Amygdala Regulates Reconsolidation of Morphine Reward Memory in Rats.GENES,13(3),16.
MLA Liu, Peng,et al."Gnas Promoter Hypermethylation in the Basolateral Amygdala Regulates Reconsolidation of Morphine Reward Memory in Rats".GENES 13.3(2022):16.

入库方式： OAI收割

来源：心理研究所

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