Transcranial alternating current stimulation for treating depression: a randomized controlled trial
文献类型：期刊论文
| 作者 | Wang, Hongxing11,12; Wang, Kun10,12; Xue, Qing12; Peng, Mao12; Yin, Lu9; Gu, Xuecun10; Leng, Haixia12; Lu, Juan10; Liu, Hongzhi10; Wang, Di10 |
| 刊名 | BRAIN
 |
| 出版日期 | 2022-03-29 |
| 卷号 | 145期号:1页码:83-91 |
| ISSN号 | 0006-8950 |
| 关键词 | drug-naive efficacy first-episode major depressive disorder transcranial alternating current stimulation |
| DOI | 10.1093/brain/awab252 |
| 通讯作者 | Wang, Hongxing(wanghongxing@xwh.ccmu.edu.cn) ; Wang, Yuping(wangyuping01@sina.cn) |
| 英文摘要 | Treatment of depression with antidepressants is partly effective. Transcranial alternating current stimulation can provide a non-pharmacological alternative for adult patients with major depressive disorder. However, no study has used the stimulation to treat first-episode and drug-naive patients with major depressive disorder. We used a randomized, double-blind, sham-controlled design to examine the clinical efficacy and safety of the stimulation in treating first-episode drug-naive patients in a Chinese Han population. From 4 June 2018 to 30 December 2019, 100 patients were recruited and randomly assigned to receive 20 daily 40-min, 77.5 Hz, 15 mA, one forehead and two mastoid sessions of active or sham stimulation (n = 50 for each group) in four consecutive weeks (Week 4), and were followed for additional 4-week efficacy/safety assessment without stimulation (Week 8). The primary outcome was a remission rate defined as the 17-item Hamilton Depression Rating Scale (HDRS-17) score <= 7 at Week 8. Secondary analyses were response rates (defined as a reduction of >= 50% in the HDRS-17), changes in depressive symptoms and severity from baseline to Week 4 and Week 8, and rates of adverse events. Data were analysed in an intention-to-treat sample. Forty-nine in the active and 46 in the sham completed the study. Twenty-seven of 50 (54%) in the active treatment group and 9 of 50 (18%) in the sham group achieved remission at the end of Week 8. The remission rate was significantly higher in the active group compared to that in the sham group with a risk ratio of 1.78 (95% confidence interval, 1.29, 2.47). Compared with the sham, the active group had a significantly higher remission rate at Week 4, response rates at Weeks 4 and 8, and a larger reduction in depressive symptoms from baseline to Weeks 4 and 8. Adverse events were similar between the groups. In conclusion, the stimulation on the frontal cortex and two mastoids significantly improved symptoms in first-episode drug-naive patients with major depressive disorder and may be considered as a non-pharmacological intervention for them in an outpatient setting. In a randomized double-blind controlled trial, Wang et al. show that 4 weeks of treatment with transcranial alternating current stimulation (tACS) reduces symptoms to a greater degree than sham stimulation in first-episode drug-naive patients with major depressive disorder. |
| 收录类别 | SCI |
| WOS关键词 | CRANIAL ELECTROTHERAPY STIMULATION ; ELECTRICAL-STIMULATION ; MAJOR DEPRESSION ; DOUBLE-BLIND ; FOLLOW-UP ; EFFICACY ; SAFETY ; PERCEPTION ; DISORDER ; INSOMNIA |
| 资助项目 | National Key R&D Program of China[2017YFC1310001] ; National Key R&D Program of China[2016YFC1307000] ; National Natural Science Foundation of China[81771862] ; Beijing Municipal Science and Technology Project[Z171100000117016] ; Beijing Natural Science Foundation[KZ201710025017] ; Beijing Municipal Hospital Research and Development Plan[PX2017069] ; Beijing Hundred, Thousand, and Ten Thousand Talents Project[2017-CXYF-09] |
| WOS研究方向 | Neurosciences & Neurology |
| 语种 | 英语 |
| 出版者 | OXFORD UNIV PRESS |
| WOS记录号 | WOS:000775227900011 |
| 资助机构 | National Key R&D Program of China ; National Natural Science Foundation of China ; Beijing Municipal Science and Technology Project ; Beijing Natural Science Foundation ; Beijing Municipal Hospital Research and Development Plan ; Beijing Hundred, Thousand, and Ten Thousand Talents Project |
| 源URL | [http://ir.psych.ac.cn/handle/311026/42367]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 通讯作者 | Wang, Hongxing; Wang, Yuping |
| 作者单位 | 1.Univ Florence, Dept Hlth Sci, I-50135 Florence, Italy 2.Case Western Reserve Univ, Sch Med, Dept Psychiat, Cleveland, OH 44106 USA 3.Johns Hopkins Univ, Dept Psychiat & Behav Sci, Sch Med, Baltimore, MD 21287 USA 4.Univ Alberta, Fac Med & Dent, Dept Psychiat, Edmonton, AB T6G 2B7, Canada 5.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing 100101, Peoples R China 6.Peking Univ, Inst Mental Hlth, Beijing 100191, Peoples R China 7.Peking Univ, Minist Hlth, Key Lab Mental Hlth, Natl Clin Res Ctr Mental Disorders,Peking Univ Si, Beijing 100191, Peoples R China 8.Carleton Coll, Dept Biol, Northfield, MN 55057 USA 9.Peking Union Med Coll & Chinese Acad Med Sci, Fuwai Hosp, Med Res & Biometr Ctr, Natl Ctr Cardiovasc Dis, Beijing, Peoples R China 10.Beijing Puren Hosp, Dept Neurol, Beijing 100062, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Hongxing,Wang, Kun,Xue, Qing,et al. Transcranial alternating current stimulation for treating depression: a randomized controlled trial[J]. BRAIN,2022,145(1):83-91. |
| APA | Wang, Hongxing.,Wang, Kun.,Xue, Qing.,Peng, Mao.,Yin, Lu.,...&Wang, Yuping.(2022).Transcranial alternating current stimulation for treating depression: a randomized controlled trial.BRAIN,145(1),83-91. |
| MLA | Wang, Hongxing,et al."Transcranial alternating current stimulation for treating depression: a randomized controlled trial".BRAIN 145.1(2022):83-91. |
入库方式： OAI收割
来源：心理研究所
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