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Cold Plasma Irradiation Regulates Inflammation and Oxidative Stress in Human Bronchial Epithelial Cells and Human Non-Small Cell Lung Carcinoma

文献类型：期刊论文

作者Sun, Tao4,5,6; Yu, Shujun3; Song, Xuegang5; Zhang, Jin2; Bao, Qin5; Mei, Qiong5; Shen, Qiying1; Wang, Dong5; Ni, Guohua4,6
刊名RADIATION RESEARCH
出版日期2022-02-01
卷号197
ISSN号0033-7587
DOI10.1667/RADE-20-00178.1
通讯作者Shen, Qiying(shenqiying-yy@163.com) ; Wang, Dong(wdwade@mail.ustc.edu.cn) ; Ni, Guohua(ghni@ipp.ac.cn)
英文摘要Atmospheric pressure cold plasma has shown multiple biological effects of anti-bacteria and anti-cancer. In this study, the effect of atmospheric pressure cold plasma on respiratory inflammation and oxidant stress is explored. Tunicamycin was used to stimulate human bronchial epithelial cells (HBECs) and A549 cells for inflammatory response and oxidative stress, followed by atmospheric pressure cold plasma treatment. For HBECs and A549 cells, atmospheric pressure cold plasma was able to alleviate tunicamycin-induced cell proliferation inhibition, inflammation and oxidant stress, and enhance nuclear factor-erythroid-2-related factor 2 (NRF2) pathway activation. Moreover, NRF2/ARE (anti-oxidant response elements) pathway was involved in the regulation of atmospheric pressure cold plasma on tunicamycin-induced oxidative stress. These results suggest the positive effect of atmospheric pressure cold plasma on inflammation and oxidant stress of respiratory system, indicating the therapeutic potential of atmospheric pressure cold plasma for respiratory diseases. (C) 2022 by Radiation Research Society
WOS关键词SYNCYTIAL VIRUS-INFECTION ; HEME OXYGENASE-1 ; KAPPA-B ; EXPRESSION ; ANTIOXIDANT ; INJURY ; RATS
资助项目National Key R&D Program of China[2019YFC0119000] ; National Natural Science Foundation of China[31800702] ; National Natural Science Foundation of China[11875295] ; National Natural Science Foundation of China[11535003] ; National Natural Science Foundation of China[81902003] ; Anhui Medical University[XJ201603] ; Anhui Medical University[2017xkj003]
WOS研究方向Life Sciences & Biomedicine - Other Topics ; Biophysics ; Radiology, Nuclear Medicine & Medical Imaging
语种英语
WOS记录号WOS:000774050400007
出版者RADIATION RESEARCH SOC
资助机构National Key R&D Program of China ; National Natural Science Foundation of China ; Anhui Medical University
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/128253]  
专题中国科学院合肥物质科学研究院
通讯作者Shen, Qiying; Wang, Dong; Ni, Guohua
作者单位1.Anhui Med Univ, Dept Anesthesiol, Affiliated Hosp 1, Hefei 230022, Anhui, Peoples R China
2.Univ Sci & Technol China, Dept Pharm, Affiliated Hosp 1, Hefei 230031, Anhui, Peoples R China
3.Anhui Med Univ, Dept Obstet & Gynecol, Affiliated Hosp 1, Hefei 230022, Anhui, Peoples R China
4.Anhui Prov Key Lab Med Phys & Technol, Hefei 230031, Anhui, Peoples R China
5.Anhui Med Univ, Sch Basic Med Sci, Hefei 230032, Anhui, Peoples R China
6.Chinese Acad Sci, Inst Plasma Phys, Hefei 230031, Anhui, Peoples R China
推荐引用方式
GB/T 7714		 Sun, Tao,Yu, Shujun,Song, Xuegang,et al. Cold Plasma Irradiation Regulates Inflammation and Oxidative Stress in Human Bronchial Epithelial Cells and Human Non-Small Cell Lung Carcinoma[J]. RADIATION RESEARCH,2022,197.
APA Sun, Tao.,Yu, Shujun.,Song, Xuegang.,Zhang, Jin.,Bao, Qin.,...&Ni, Guohua.(2022).Cold Plasma Irradiation Regulates Inflammation and Oxidative Stress in Human Bronchial Epithelial Cells and Human Non-Small Cell Lung Carcinoma.RADIATION RESEARCH,197.
MLA Sun, Tao,et al."Cold Plasma Irradiation Regulates Inflammation and Oxidative Stress in Human Bronchial Epithelial Cells and Human Non-Small Cell Lung Carcinoma".RADIATION RESEARCH 197(2022).

入库方式： OAI收割

来源：合肥物质科学研究院

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