Clinical features and prognosis of resectable pulmonary primary invasive mucinous adenocarcinoma
文献类型：期刊论文
| 作者 | Xu, Xiaoling7,8; Shen, Wenming6; Wang, Ding5,7; Li, Na4; Huang, Zhiyu7,8; Sheng, Jiamin7,8; Rucker, A. Justin3; Mao, Weimin2,7; Xu, Haimiao1,7; Cheng, Guoping1,7 |
| 刊名 | TRANSLATIONAL LUNG CANCER RESEARCH
 |
| 出版日期 | 2022-03-01 |
| 卷号 | 11 |
| ISSN号 | 2218-6751 |
| 关键词 | Non-small cell lung cancer (NSCLC) pulmonary invasive mucinous adenocarcinoma propensity-matched analysis prognosis |
| DOI | 10.21037/tlcr-22-190 |
| 通讯作者 | Mao, Weimin(maowm1318@163.com) ; Xu, Haimiao(xuhm@zjcc.org.cn) ; Cheng, Guoping(chengguoping1218@163.com) |
| 英文摘要 | Background: According to the latest the World Health Organization (WHO) classification in 2015, invasive mucinous adenocarcinoma (IMA) is defined as a new pathological subtype of lung adenocarcinoma (LUAD). However, whether this rare subtype of lung pathology has any difference in prognosis than conventional LUAD is debatable. Our study attempted to compare clinical characteristics and prognosis of IMA vs. noninvasive mucinous adenocarcinomas (NMA). Methods: A total of 1,857 patients with LUAD who underwent radical resection were screened from 2010 to 2015 at Zhejiang Cancer Hospital. Patients with pulmonary IMA were matched 1:1 by using propensity scores with LUAD adjusted for clinicopathological characteristics. After follow-up, overall survival (OS) and disease-free survival (DFS) were explored by Kaplan-Meier and Cox regression analyses. Forest plots were used for subgroup analyses. Results: Following screening, 499 patients with LUAD were enrolled, with 97 IMA and 402 NMA. Compared to NMA of the lung, IMA was proportionately lower in women (50.5% vs. 63.4%; P=0.026) and nonsmokers (P<0.001). IMA was also associated with earlier tumor stage I (68.0% vs. 55.5%; P=0.033) and lower frequency of upper lobe tumors compared to NMA (P=0.007). Following propensity score matching, 97 pairs were selected, among which we found that patients with pulmonary IMA had a longer OS than those with NMA (P=0.014). According to the subgroup analysis, improved OS in the IMA cohort versus the NMA cohort was observed across various factors, including the absence of lymphovascular invasion or perineural invasion. Conclusions: In this study, we found that resectable IMA patients had a better OS than NMA patients. This study contributes to the understanding of IMA in depth, but it needs to be validated through additional multicenter studies. |
| WOS关键词 | INTERNATIONAL MULTIDISCIPLINARY CLASSIFICATION ; LUNG ADENOCARCINOMA ; ASSOCIATION ; SOCIETY ; SURVIVAL ; SUBGROUPS ; RELEVANCE |
| 资助项目 | AME Lung Cancer Collaborative Group ; National Natural Science Foundation of China[81802995] ; National Natural Science Foundation of China[81672315] ; Key R&D Program Projects in Zhejiang Province[2017C04G1360498] |
| WOS研究方向 | Oncology ; Respiratory System |
| 语种 | 英语 |
| 出版者 | AME PUBL CO |
| WOS记录号 | WOS:000774223200001 |
| 资助机构 | AME Lung Cancer Collaborative Group ; National Natural Science Foundation of China ; Key R&D Program Projects in Zhejiang Province |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/128259]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Mao, Weimin; Xu, Haimiao; Cheng, Guoping |
| 作者单位 | 1.Univ Chinese Acad Sci, Zhejiang Canc Hosp, Canc Hosp, Dept Pathol, Hangzhou, Peoples R China 2.Univ Chinese Acad Sci, Zhejiang Canc Hosp, Zhejiang Key Lab Diag & Treatment Technol Thorac, Canc Hosp, Hangzhou, Peoples R China 3.Duke Univ, Med Ctr, Dept Surg, Div Cardiovasc & Thorac Surg, Durham, NC 27710 USA 4.Shaoxing 2 Hosp Med Community, Gen Hosp, Shaoxing, Peoples R China 5.Zhejiang Chinese Med Univ, Clin Med Coll 2, Hangzhou, Peoples R China 6.Ningbo Yinzhou 2 Hosp, Dept Cardiothorac Surg, Ningbo, Peoples R China 7.Chinese Acad Sci, Inst Canc & Basic Med IBMC, Hangzhou, Peoples R China 8.Univ Chinese Acad Sci, Zhejiang Canc Hosp, Canc Hosp, Dept Thorac Oncol, Hangzhou, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, Xiaoling,Shen, Wenming,Wang, Ding,et al. Clinical features and prognosis of resectable pulmonary primary invasive mucinous adenocarcinoma[J]. TRANSLATIONAL LUNG CANCER RESEARCH,2022,11. |
| APA | Xu, Xiaoling.,Shen, Wenming.,Wang, Ding.,Li, Na.,Huang, Zhiyu.,...&Cheng, Guoping.(2022).Clinical features and prognosis of resectable pulmonary primary invasive mucinous adenocarcinoma.TRANSLATIONAL LUNG CANCER RESEARCH,11. |
| MLA | Xu, Xiaoling,et al."Clinical features and prognosis of resectable pulmonary primary invasive mucinous adenocarcinoma".TRANSLATIONAL LUNG CANCER RESEARCH 11(2022). |
入库方式： OAI收割
来源：合肥物质科学研究院
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