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Disease progression patterns and molecular resistance mechanisms to crizotinib of lung adenocarcinoma harboring ROS1 rearrangements

文献类型：期刊论文

作者Zhang, Yongchang7,8; Huang, Zhe7,8; Zeng, Liang8; Zhang, Xiangyu8; Li, Yizhi8; Xu, Qinqin6; Yang, Haiyan8; Lizaso, Analyn5; Xu, Chunwei4; Liu, Jun3
刊名NPJ PRECISION ONCOLOGY
出版日期2022-03-31
卷号6
DOI10.1038/s41698-022-00264-w
通讯作者Zhang, Yongchang(zhangyongchang@csu.edu.cn) ; Yang, Nong(yangnong0217@163.com)
英文摘要This retrospective study investigated the association between the pattern of disease progression and molecular mechanism of acquired resistance in a large cohort of 49 patients with ROS1-rearranged advanced non-small-cell lung cancer treated with first-line crizotinib. We found that treatment-emergent ROS1 point mutations were the major molecular mechanism of crizotinib resistance, particularly for patients who developed extracranial-only disease progression. Our findings highlight the importance of rebiopsy and gene testing for subsequent-line therapeutic management.
资助项目Natural Science Foundation of Hunan Province[2020SK2031] ; Natural Science Foundation of Hunan Province[kq1801102] ; Natural Science Foundation of Hunan Province[2020SK2030] ; Natural Science Foundation of Hunan Province[2018RS3106] ; Natural Science Foundation of Hunan Province[2019-TJ-N04] ; Natural Science Foundation of Hunan Province[2019SK4010] ; Natural Science Foundation of Hunan Province[2020JJ3025] ; CAS Light of West China Program
WOS研究方向Oncology
语种英语
WOS记录号WOS:000776827100001
出版者NATURE PORTFOLIO
资助机构Natural Science Foundation of Hunan Province ; CAS Light of West China Program
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/128269]  
专题中国科学院合肥物质科学研究院
通讯作者Zhang, Yongchang; Yang, Nong
作者单位1.Univ Calif Irvine, Chao Family Comprehens Canc Ctr, Dept Med, Div Hematol Oncol,Sch Med, Orange, CA USA
2.Univ Chinese Acad Sci, Dept Med Oncol, Canc Hosp, Zhejiang Canc Hosp, Hangzhou 310022, Zhejiang, Peoples R China
3.Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Canc Ctr, Wuhan 430022, Peoples R China
4.Nanjing Univ, Jinling Hosp, Dept Resp Med, Sch Med, Nanjing, Peoples R China
5.Burning Rock Biotech, Guangzhou 510300, Peoples R China
6.Qinghai Prov Peoples Hosp, Dept Med Oncol, Xining 810000, Peoples R China
7.Univ South China, Grad Collaborat Training Base, Hengyang Med Sch, Hunan Canc Hosp, Hengyang 421001, Hunan, Peoples R China
8.Cent South Univ, Hunan Canc Hosp, Dept Med Oncol,Xiangya Sch Med, Lung Canc & Gastrointestinal Unit,Affiliated Canc, Changsha 410013, Peoples R China
推荐引用方式
GB/T 7714		 Zhang, Yongchang,Huang, Zhe,Zeng, Liang,et al. Disease progression patterns and molecular resistance mechanisms to crizotinib of lung adenocarcinoma harboring ROS1 rearrangements[J]. NPJ PRECISION ONCOLOGY,2022,6.
APA Zhang, Yongchang.,Huang, Zhe.,Zeng, Liang.,Zhang, Xiangyu.,Li, Yizhi.,...&Yang, Nong.(2022).Disease progression patterns and molecular resistance mechanisms to crizotinib of lung adenocarcinoma harboring ROS1 rearrangements.NPJ PRECISION ONCOLOGY,6.
MLA Zhang, Yongchang,et al."Disease progression patterns and molecular resistance mechanisms to crizotinib of lung adenocarcinoma harboring ROS1 rearrangements".NPJ PRECISION ONCOLOGY 6(2022).

入库方式： OAI收割

来源：合肥物质科学研究院

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