Potential inhibitors of microglial activation from the roots of Vernicia montana Lour
文献类型：期刊论文
| 作者 | Wang,Yingjie; Chen,Gang; Meng,Qingqi; Yao,Xiaohu; Li,Yang; Cao,Honglin; Lin,Bin; Hou,Yue; Zhou,Di; Li,Ning |
| 刊名 | PHYTOCHEMISTRY
 |
| 出版日期 | 2022 |
| 卷号 | 194页码:113019 |
| 关键词 | Vernicia montana Lour Euphorbiaceae Terpenoids Lignans Microglia ANTIINFLAMMATORY ACTIVITIES MULTIDRUG-RESISTANCE CONSTITUENTS TERPENOIDS NEOLIGNANS DITERPENES LEAVES OIL |
| ISSN号 | 0031-9422 |
| DOI | 10.1016/j.phytochem.2021.113019 |
| 英文摘要 | During our continuous investigation of natural, herbal inhibitors of microglial over-activation in the Euphorbiaceae family, two plants of the Vernicia genus showed remarkable inhibitory effects on nitric oxide (NO) production in over-activated microglia. In this study, bioactivity-guided phytochemical research on the active fraction of the roots of V. montana was carried out. As a result, seven undescribed terpenoids and lignans, together with thirty-one known components, were isolated and identified using comprehensive spectral analysis. All the identified compounds were evaluated for their inhibitory effects on NO production in lipopolysaccharidestimulated BV-2 cells. Combined with our previous research on the Vernicia genus, the effective material basis of different plants and medicinal components was analyzed systematically. |
| WOS记录号 | WOS:000723417800004 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/73004]  |
| 专题 | 中国科学院昆明植物研究所 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Yunnan, Peoples R China 2.Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med, Wenhua Rd 103, Shenyang 110016, Peoples R China 3.Northeastern Univ, Coll Life & Hlth Sci, Shenyang 110004, Peoples R China 4.Chinese Acad Sci, South China Bot Garden, Guangzhou 510650, Peoples R China 5.Shenyang Pharmaceut Univ, Sch Pharmaceut Engn, Shenyang 110016, Peoples R China 6.Guangxi Normal Univ, Sate Key Lab Chem & Mol Engn Med Resources, Nanning, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang,Yingjie,Chen,Gang,Meng,Qingqi,et al. Potential inhibitors of microglial activation from the roots of Vernicia montana Lour[J]. PHYTOCHEMISTRY,2022,194:113019. |
| APA | Wang,Yingjie.,Chen,Gang.,Meng,Qingqi.,Yao,Xiaohu.,Li,Yang.,...&Li,Ning.(2022).Potential inhibitors of microglial activation from the roots of Vernicia montana Lour.PHYTOCHEMISTRY,194,113019. |
| MLA | Wang,Yingjie,et al."Potential inhibitors of microglial activation from the roots of Vernicia montana Lour".PHYTOCHEMISTRY 194(2022):113019. |
入库方式： OAI收割
来源：昆明植物研究所
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