Stereodivergent Strategy in Structural Determination: Asymmetric Total Synthesis of Garcinol, Cambogin, and Related Analogues
文献类型：期刊论文
| 作者 | Wang,Xueying; Phang,Yeelin; Feng,Jiling; Liu,Song; Zhang,Hong; Fu,Wenwei; Zhou,Hua; Xu,Gang ; Xu,Hongxi; Zheng,Changwu
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| 刊名 | ORGANIC LETTERS
 |
| 出版日期 | 2021 |
| 卷号 | 23期号:11页码:4203-4208 |
| 关键词 | POLYCYCLIC POLYPRENYLATED ACYLPHLOROGLUCINOLS PRENYLATED BENZOYLPHLOROGLUCINOLS ABSOLUTE-CONFIGURATION GUTTIFERONE F BENZOPHENONE DERIVATIVES ASSIGNMENT MULTIFLORA |
| ISSN号 | 1523-7060 |
| DOI | 10.1021/acs.orglett.1c01139 |
| 英文摘要 | The asymmetric total synthesis of five biologically significant polycyclic polyprenylated acylphloroglucinols (PPAPs), including garcinol and cambogin, was achieved through a highly diastereoselective and stereodivergent strategy. Along the way, an efficient cascade Dieckmann cyclization was employed to construct the bicyclo[3.3.1]nonane core in one step. The synthesis provided a general approach toward the chiral endo-type B PPAPs and their C-30 diastereomers in a single sequence, which resolved the challenges of the absolute configuration determination/structural revision of PPAPs bearing exocyclic stereocenters. |
| WOS记录号 | WOS:000661126700023 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/73008]  |
| 专题 | 中国科学院昆明植物研究所 |
| 作者单位 | 1.Shanghai Univ Tradit Chinese Med, Sch Pharm, Shanghai 201203, Peoples R China 2.Shanghai Univ Tradit Chinese Med, Shuguang Hosp, Shanghai 201203, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Synthet Chem Nat Subst, Shanghai 200032, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang,Xueying,Phang,Yeelin,Feng,Jiling,et al. Stereodivergent Strategy in Structural Determination: Asymmetric Total Synthesis of Garcinol, Cambogin, and Related Analogues[J]. ORGANIC LETTERS,2021,23(11):4203-4208. |
| APA | Wang,Xueying.,Phang,Yeelin.,Feng,Jiling.,Liu,Song.,Zhang,Hong.,...&Zheng,Changwu.(2021).Stereodivergent Strategy in Structural Determination: Asymmetric Total Synthesis of Garcinol, Cambogin, and Related Analogues.ORGANIC LETTERS,23(11),4203-4208. |
| MLA | Wang,Xueying,et al."Stereodivergent Strategy in Structural Determination: Asymmetric Total Synthesis of Garcinol, Cambogin, and Related Analogues".ORGANIC LETTERS 23.11(2021):4203-4208. |
入库方式： OAI收割
来源：昆明植物研究所
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