Rhynchines A-E: Ca(v)3.1 Calcium Channel Blockers from Uncaria rhynchophylla
文献类型：期刊论文
| 作者 | Zhou,Hao-Feng; Li,Wen-Yan; Peng,Li-Yan; Li,Xiao-Nian; Zuo,Zhi-Li; Zhao,Qin-Shi |
| 刊名 | ORGANIC LETTERS
 |
| 出版日期 | 2021 |
| 卷号 | 23期号:24页码:9463-9467 |
| ISSN号 | 1523-7060 |
| 关键词 | INDOLE ALKALOIDS |
| DOI | 10.1021/acs.orglett.1c03641 |
| 英文摘要 | Rhynchines A-E (1-5), five new indole alkaloids with an unprecedented skeleton, were isolated from Uncaria rhynchophylla. The new skeleton was characterized by an indole moiety and a 2-oxa-8-azatricyclo[6,5,0(1,5), 0(1,8)]tridecane core, forming a unique 6/5/7/5/5 ring system. Their structures were determined by nuclear magnetic resonance, high-resolution electrospray ionization mass spectrometry, infrared spectroscopy, and calculated electronic circular dichroism (ECD) and were confirmed by X-ray crystallography. Interestingly, 1 and 2 showed strong inhibitory activities against the Ca-v 3.1 calcium channel with IC50 values of 6.86 and 10.41 mu M. |
| WOS记录号 | WOS:000744124300024 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/73012]  |
| 专题 | 中国科学院昆明植物研究所 |
| 作者单位 | 1.Li, Wen-Yan 2.Peng, Li-Yan 3.[Zhou, Hao-Feng 4.Li, Xiao-Nian 5.Zuo, Zhi-Li 6.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 7.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhou,Hao-Feng,Li,Wen-Yan,Peng,Li-Yan,et al. Rhynchines A-E: Ca(v)3.1 Calcium Channel Blockers from Uncaria rhynchophylla[J]. ORGANIC LETTERS,2021,23(24):9463-9467. |
| APA | Zhou,Hao-Feng,Li,Wen-Yan,Peng,Li-Yan,Li,Xiao-Nian,Zuo,Zhi-Li,&Zhao,Qin-Shi.(2021).Rhynchines A-E: Ca(v)3.1 Calcium Channel Blockers from Uncaria rhynchophylla.ORGANIC LETTERS,23(24),9463-9467. |
| MLA | Zhou,Hao-Feng,et al."Rhynchines A-E: Ca(v)3.1 Calcium Channel Blockers from Uncaria rhynchophylla".ORGANIC LETTERS 23.24(2021):9463-9467. |
入库方式： OAI收割
来源：昆明植物研究所
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