New cytotoxic dichapetalins in the leaves of Phyllanthus acidus: Identification, quantitative analysis, and preliminary toxicity assessment
文献类型：期刊论文
| 作者 | Geng,Hui-Chun; Zhu,Hong-Tao; Yang,Wei-Nong; Wang,Dong ; Yang,Chong-Ren; Zhang,Ying-Jun
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| 刊名 | BIOORGANIC CHEMISTRY
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| 出版日期 | 2021 |
| 卷号 | 114页码:105125 |
| 关键词 | Phyllanthus acidus Euphorbiaceae Dichapetalins Pacidusins A-D Cytotoxicity TRITERPENOIDS CONSTITUENTS |
| ISSN号 | 0045-2068 |
| DOI | 10.1016/j.bioorg.2021.105125 |
| 英文摘要 | The young leaves of Phyllanthus acidus (Euphorbiaceae) are commonly used as edible vegetables in Indonesia, Thailand, and India, and their water infusions as dieting aids for people trying to remain slim. However, it is regarded as a poisonous plant in Malaya, and current researches are insufficient to provide a conclusion on its toxicity and safety under large doses. In this study, we firstly found that the refined nonpolar extracts of P. acidus leaves showed significant cytotoxic effect against BEAS-2B and L02 normal cell lines with IC50 values of 2.15 and 1.64 mg/mL, respectively. Further bioactivity-guided isolation produced four new rare dichapetalins (pacidusins A-D) from the most active fraction. Their structures including absolute configurations were elucidated by extensive spectroscopic data and X-ray diffraction analysis. All the isolated dichapetalins exhibited moderate cytotoxicity against, BEAS-2B and L02 normal cell lines with IC50 values ranging from 12.44 to 22.55 mu M, as well as five human cancer cell lines with IC50 values ranging from 3.38 to 22.38 mu M. Furthermore, the content of the main dichapetalins in the leaves were determined by analytical HPLC, which showed that the leaves contained a very high amount of the four isolated dichapetalins with a total yield of 0.488 mg/g of dry plant material. These toxic dichapetalins may lead to adverse health effects in higher doses. Our findings indicate that the dichapetalin containing leaves may not be suitable for consumption in large quantities as food, but demonstrate their potency as anti-cancer agents for new drug discovery. |
| WOS记录号 | WOS:000691056700003 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/73040]  |
| 专题 | 中国科学院昆明植物研究所 |
| 作者单位 | 1.Zhu, Hong-Tao 2.Wang, Dong 3.Yang, Chong-Ren 4.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 5.Yunnan Xinxing Greening Engn Co, Kunming 650228, Yunnan, Peoples R China 6.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 7.Chinese Acad Sci, Kunming Inst Bot, Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China 8.[Geng, Hui-Chun |
| 推荐引用方式 GB/T 7714 | Geng,Hui-Chun,Zhu,Hong-Tao,Yang,Wei-Nong,et al. New cytotoxic dichapetalins in the leaves of Phyllanthus acidus: Identification, quantitative analysis, and preliminary toxicity assessment[J]. BIOORGANIC CHEMISTRY,2021,114:105125. |
| APA | Geng,Hui-Chun,Zhu,Hong-Tao,Yang,Wei-Nong,Wang,Dong,Yang,Chong-Ren,&Zhang,Ying-Jun.(2021).New cytotoxic dichapetalins in the leaves of Phyllanthus acidus: Identification, quantitative analysis, and preliminary toxicity assessment.BIOORGANIC CHEMISTRY,114,105125. |
| MLA | Geng,Hui-Chun,et al."New cytotoxic dichapetalins in the leaves of Phyllanthus acidus: Identification, quantitative analysis, and preliminary toxicity assessment".BIOORGANIC CHEMISTRY 114(2021):105125. |
入库方式： OAI收割
来源：昆明植物研究所
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