Alkaloids from Tabernaemontana divaricata combined with fluconazole to overcome fluconazole resistance in Candida albicans
文献类型：期刊论文
| 作者 | Zhang,Yu ; Bai,Xue; Yuwen,Huan-Sha; Guo,Ling-Li; Liu,Jian-Wen; Hao,Xiao-Jiang
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| 刊名 | BIOORGANIC CHEMISTRY
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| 出版日期 | 2021 |
| 卷号 | 107页码:104515 |
| 关键词 | Tabernaemontana divaricate Taberdines A-K Reversal of fluconazole resistance Candida albicans |
| ISSN号 | 0045-2068 |
| DOI | 10.1016/j.bioorg.2020.104515 |
| 英文摘要 | Nineteen indole alkaloids including eleven new ones, taberdines A-K (1-11), were isolated from Tabernaemontana divaricata. Their structures were assigned by MS, NMR, single crystal X-ray diffractions, and ECD analyses. Alkaloid 1 is an aspidosperma-type monoterpenoid indole alkaloid and possesses a rearranged pyrrolidine moiety due to C-3 degradation, and 4 has a rare 1,3-oxazolidine moiety within iboga-type alkaloids. Alkaloids 2, 4, 6, and 11-19 combined with 5 mu g/mL fluconazole exhibited significant activity to reverse fluconazole resistance in Candida albicans strains while no one used alone showed any activities against the resistant strain. |
| WOS记录号 | WOS:000618105400002 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/73046]  |
| 专题 | 中国科学院昆明植物研究所 |
| 作者单位 | 1.Guo, Ling-Li 2.Liu, Jian-Wen 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 4.[Zhang, Yu 5.Bai, Xue 6.Yuwen, Huan-Sha |
| 推荐引用方式 GB/T 7714 | Zhang,Yu,Bai,Xue,Yuwen,Huan-Sha,et al. Alkaloids from Tabernaemontana divaricata combined with fluconazole to overcome fluconazole resistance in Candida albicans[J]. BIOORGANIC CHEMISTRY,2021,107:104515. |
| APA | Zhang,Yu,Bai,Xue,Yuwen,Huan-Sha,Guo,Ling-Li,Liu,Jian-Wen,&Hao,Xiao-Jiang.(2021).Alkaloids from Tabernaemontana divaricata combined with fluconazole to overcome fluconazole resistance in Candida albicans.BIOORGANIC CHEMISTRY,107,104515. |
| MLA | Zhang,Yu,et al."Alkaloids from Tabernaemontana divaricata combined with fluconazole to overcome fluconazole resistance in Candida albicans".BIOORGANIC CHEMISTRY 107(2021):104515. |
入库方式： OAI收割
来源：昆明植物研究所
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