Discovery of quality markers in Rubus Chingii Hu using UPLC-ESI-QTOF-MS
文献类型：期刊论文
| 作者 | Zhou,Zi-Meng; Yan,Dong-Mei; Wang,Yi-Kun; Zhang,Ting; Xiao,Xue-Rong; Dai,Man-Yun; Zhang,Shou-Wen; Liu,Hong-Ning; Li,Fei |
| 刊名 | JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
 |
| 出版日期 | 2021 |
| 卷号 | 203页码:114200 |
| ISSN号 | 0731-7085 |
| 关键词 | Raspberry Q-markers Quality evaluation UPLC-ESI-QTOF-MS COMPONENTS ACTIVATION PATHWAY FRUITS |
| DOI | 10.1016/j.jpba.2021.114200 |
| 英文摘要 | Raspberry, the fruit of Rubus Chingii Hu, has been used as a traditional Chinese medicine (TCM) to nourish kidney and strengthen Yang-qi. In order to determine the quality of raspberry, the quality markers (Q-markers) of raspberry that can improve renal function were investigated using UPLC-ESI-QTOF-MS in this study. The results of serum pharmacochemistry indicated that six components rutin, ellagic acid, kaempferol-3-rutinoside, astragalin, tiliroside, and goshonoside F5 in raspberry were absorbed into rat blood. The HEK293 cells treated with cisplatin were used to evaluate the kidney-protecting activity of these absorbed components. All these components could markedly inhibit cell damage induced by cisplatin and restore the levels of malondialdehyde (MDA) and catalase (CAT) in the cells, suggesting that these components may be the Q-markers of raspberry. More importantly, except for ellagic acid, other five Q-markers in raspberries from Dexing of Jiangxi province were higher than those from most of other areas. It is well known that Dexing raspberry is the Dao-di herbs raspberry used in the clinic of Chinese Medicine, demonstrating that these components could be used as Q-markers of raspberry. This study provides a reliable and valuable method for quality evaluation of raspberry. (c) 2021 Elsevier B.V. All rights reserved. |
| WOS记录号 | WOS:000681070000002 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/73053]  |
| 专题 | 中国科学院昆明植物研究所 |
| 作者单位 | 1.Sichuan Univ, West China Hosp, Frontiers Sci Ctr Dis Related Mol Network, Lab Metabol & Drug Induced Liver Injury, Chengdu 610000, Peoples R China 2.Jiangxi Univ Chinese Med, Academician Workstn, Nanchang 330004, Jiangxi, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 5.Jiangxi Univ Chinese Med, Res Ctr Nat Resources Chinese Med Mat & Ethn Med, Nanchang 33004, Jiangxi, Peoples R China 6.China Natl Inst Standardizat, Subinst Food & Agr Standardizat, Beijing 100191, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhou,Zi-Meng,Yan,Dong-Mei,Wang,Yi-Kun,et al. Discovery of quality markers in Rubus Chingii Hu using UPLC-ESI-QTOF-MS[J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,2021,203:114200. |
| APA | Zhou,Zi-Meng.,Yan,Dong-Mei.,Wang,Yi-Kun.,Zhang,Ting.,Xiao,Xue-Rong.,...&Li,Fei.(2021).Discovery of quality markers in Rubus Chingii Hu using UPLC-ESI-QTOF-MS.JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,203,114200. |
| MLA | Zhou,Zi-Meng,et al."Discovery of quality markers in Rubus Chingii Hu using UPLC-ESI-QTOF-MS".JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 203(2021):114200. |
入库方式： OAI收割
来源：昆明植物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。