Labdane and isopimarane diterpenoids from Rosmarinus officinalis solid wastes: MS/MS spectrometric fragmentations and neuroprotective effect
文献类型：期刊论文
| 作者 | Chen,Xinglong; Luo,Qingyi; Hu,Weiyan; Chen,Jijun ; Zhang,Rongping
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| 刊名 | INDUSTRIAL CROPS AND PRODUCTS
 |
| 出版日期 | 2022 |
| 卷号 | 177页码:114441 |
| ISSN号 | 0926-6690 |
| 关键词 | Rosmarinus officinalis Solid wastes Labdane diterpenoids Isopimarane diterpenoids MS/MS fragmentations Neuroprotective effect CARNOSIC ACID ANTIOXIDANT ACTIVITY BIOSYNTHESIS |
| DOI | 10.1016/j.indcrop.2021.114441 |
| 英文摘要 | The aim of this study was to purify and identify new types of secondary products from Rosmarinus officinalis solid wastes after essential oil been extracted, further study their MS/MS spectrometric fragmentations and evaluate their cytoprotective effects against H2O2-induced oxidative damage in SH-SY5Y cells. Six labdane diterpenoids, five isopimarane diterpenoids and two ferulic acid esters were obtained in which three labdane diterpenoids and four isopimarane diterpenoids were undescribed compounds. The losses of hydroxyl, tigloyl, 2-methy-butanoyl, acetyl and carbonyl groups or side chains were the main elimination modes of the new compounds in MS/MS analyses. Compounds 1, 4, 6, 10 and 12 showed the ability to protect the cells against oxidative injure whose cell viability rates were more than 65% in the concentration of 1 or 25 mu M respectively. These studies broadened the understanding of secondary products of rosemary and promoted the deep developments and utilizations of rosemary after essential oil been extracted. |
| WOS记录号 | WOS:000736973700008 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/73068]  |
| 专题 | 中国科学院昆明植物研究所 |
| 作者单位 | 1.Kunming Med Univ, Sch Pharmaceut Sci, Kunming 650500, Yunnan, Peoples R China 2.Yunnan Univ Chinese Med, Sch Chinese Mat Med, Kunming 650500, Yunnan, Peoples R China 3.Yunnan Univ Chinese Med, Yunnan Key Lab Southern Med Utilizat, Kunming 650500, Yunnan, Peoples R China 4.Kunming Med Univ, Yunnan Key Lab Pharmacol Nat Prod, Kunming 650500, Yunnan, Peoples R China 5.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen,Xinglong,Luo,Qingyi,Hu,Weiyan,et al. Labdane and isopimarane diterpenoids from Rosmarinus officinalis solid wastes: MS/MS spectrometric fragmentations and neuroprotective effect[J]. INDUSTRIAL CROPS AND PRODUCTS,2022,177:114441. |
| APA | Chen,Xinglong,Luo,Qingyi,Hu,Weiyan,Chen,Jijun,&Zhang,Rongping.(2022).Labdane and isopimarane diterpenoids from Rosmarinus officinalis solid wastes: MS/MS spectrometric fragmentations and neuroprotective effect.INDUSTRIAL CROPS AND PRODUCTS,177,114441. |
| MLA | Chen,Xinglong,et al."Labdane and isopimarane diterpenoids from Rosmarinus officinalis solid wastes: MS/MS spectrometric fragmentations and neuroprotective effect".INDUSTRIAL CROPS AND PRODUCTS 177(2022):114441. |
入库方式： OAI收割
来源：昆明植物研究所
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