Polycyclic polyprenylated acylphloroglucinol congeners from Garcinia yunnanensis Hu with inhibitory effect on alpha-hemolysin production in Staphylococcus aureus
文献类型：期刊论文
| 作者 | Zheng,Dan; Chen,Yuyu; Wan,Shijie; Jiang,Jiaming; Chen,Simin; Zheng,Changwu; Zhou,Hua; Xu,Gang ; Zhang,Hong; Xu,Hongxi
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| 刊名 | BIOORGANIC CHEMISTRY
 |
| 出版日期 | 2021 |
| 卷号 | 114页码:105074 |
| 关键词 | Garcinia yunnanensis Hu Polycyclic polyprenylated acylphloroglucinols (PPAPs) Staphylococcus aureus alpha-Hemolysin (Hla) BENZOPHENONE DERIVATIVES OBLONGIFOLIN C GUTTIFERONE-K NEUTRALIZATION CALCICOLA VIRULENCE COMPOUND GENE MRSA |
| ISSN号 | 0045-2068 |
| DOI | 10.1016/j.bioorg.2021.105074 |
| 英文摘要 | alpha-Hemolysin (Hla) is an extracellular protein secreted by methicillin-resistant Staphylococcus aureus (MRSA) strains that plays a critical role in the pathogenesis of pulmonary, intraperitoneal, intramammary, and corneal infections, rendering Hla a potential therapeutic target. In this study, 10 unreported polycyclic polyprenylated acylphloroglucinol (PPAP) derivatives, garciyunnanins C-L (1-10), with diverse skeletons, were isolated from Garcinia yunnanensis Hu. The structures of these new compounds were determined by HRMS, NMR, electronic circular dichroism (ECD) calculations, single-crystal X-ray diffraction, and biomimetic transformation. Garciyunnanins C and D (1 and 2) were found to be potent Hla inhibitors in the anti-virulence efficacy evaluation against MRSA strain. |
| WOS记录号 | WOS:000689498000005 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/73083]  |
| 专题 | 中国科学院昆明植物研究所 |
| 作者单位 | 1.Shanghai Jiao Tong Univ Affiliated Peoples Hosp 6, Ctr Translat Med, Shanghai 200233, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China 4.Shanghai Univ Tradit Chinese Med, Sch Pharm, Shanghai 201203, Peoples R China 5.Shanghai Univ Tradit Chinese Med, Shuguang Hosp, Inst Cardiovasc Dis Integrated Tradit Chinese & W, Shanghai 201203, Peoples R China 6.Shanghai Jiao Tong Univ Affiliated Peoples Hosp 6, Shanghai Key Lab Diabet Mellitus, Shanghai 200233, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zheng,Dan,Chen,Yuyu,Wan,Shijie,et al. Polycyclic polyprenylated acylphloroglucinol congeners from Garcinia yunnanensis Hu with inhibitory effect on alpha-hemolysin production in Staphylococcus aureus[J]. BIOORGANIC CHEMISTRY,2021,114:105074. |
| APA | Zheng,Dan.,Chen,Yuyu.,Wan,Shijie.,Jiang,Jiaming.,Chen,Simin.,...&Xu,Hongxi.(2021).Polycyclic polyprenylated acylphloroglucinol congeners from Garcinia yunnanensis Hu with inhibitory effect on alpha-hemolysin production in Staphylococcus aureus.BIOORGANIC CHEMISTRY,114,105074. |
| MLA | Zheng,Dan,et al."Polycyclic polyprenylated acylphloroglucinol congeners from Garcinia yunnanensis Hu with inhibitory effect on alpha-hemolysin production in Staphylococcus aureus".BIOORGANIC CHEMISTRY 114(2021):105074. |
入库方式： OAI收割
来源：昆明植物研究所
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