Hypermoins A-D: Rearranged Nor-Polyprenylated Acylphloroglucinols from the Flowers of Hypericum monogynum
文献类型：期刊论文
| 作者 | Zeng,Yan-Rong; Li,Ya-Nan; Zhang,Zi-Zhen; Hu,Zhan-Xing; Gu,Wei ; Huang,Lie-Jun; Li,Yan-Mei; Yuan,Chun-Mao; Hao,Xiao-Jiang
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| 刊名 | JOURNAL OF ORGANIC CHEMISTRY
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| 出版日期 | 2021 |
| 卷号 | 86期号:10页码:7021-7027 |
| 关键词 | MULTIDRUG-RESISTANCE DITERPENOIDS DERIVATIVES PLANT |
| ISSN号 | 0022-3263 |
| DOI | 10.1021/acs.joc.0c02880 |
| 英文摘要 | Hypermonins A-D (1-4), four rearranged nor-polycyclic polyprenylated acylphloroglucinols (PPAPs) with unprecedented skeletons, together with two new biosynthesis related PPAPs (5 and 6) were isolated and identified from the flowers of Hypericum monogynum. Hypermoins A-D represented the first examples of highly modified norPPAPs characterized by a rare 7/6/6/5-tetracyclic system. From the biogenic synthesis pathway analysis, all isolates shared the same biosynthetic intermediate, and the addition of two methyls or one methyl to this intermediate through methyltranferase could generate different types of PPAPs (1-7). Their planner structures as well as absolute configuration were confirmed via spectroscopic analysis, ECD calculation, and X-ray crystallography. All isolates potentially reversed multidrug resistance (MDR) activity in both two cancer cells, HepG2/ADR and MCF-7/ADR. Specifically, hypermoin E (5) and hyperielliptone HA (7) were found to be the best MDR modulators with the reversal fold ranging from 41 to 236, which is higher than the positive control verapamil. |
| WOS记录号 | WOS:000656056500001 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/73100]  |
| 专题 | 中国科学院昆明植物研究所 |
| 作者单位 | 1.Gu, Wei 2.Huang, Lie-Jun 3.Zhang, Zi-Zhen 4.Hu, Zhan-Xing 5.Li, Yan-Mei 6.Guizhou Med Univ, State Key Lab Funct & Applicat Med Plants, Guiyang 550014, Peoples R China 7.Yuan, Chun-Mao 8.Key Lab Chem Nat Prod Guizhou Prov, Guiyang 550014, Peoples R China 9.Chinese Acad Sci, Guiyang 550014, Peoples R China 10.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zeng,Yan-Rong,Li,Ya-Nan,Zhang,Zi-Zhen,et al. Hypermoins A-D: Rearranged Nor-Polyprenylated Acylphloroglucinols from the Flowers of Hypericum monogynum[J]. JOURNAL OF ORGANIC CHEMISTRY,2021,86(10):7021-7027. |
| APA | Zeng,Yan-Rong.,Li,Ya-Nan.,Zhang,Zi-Zhen.,Hu,Zhan-Xing.,Gu,Wei.,...&Hao,Xiao-Jiang.(2021).Hypermoins A-D: Rearranged Nor-Polyprenylated Acylphloroglucinols from the Flowers of Hypericum monogynum.JOURNAL OF ORGANIC CHEMISTRY,86(10),7021-7027. |
| MLA | Zeng,Yan-Rong,et al."Hypermoins A-D: Rearranged Nor-Polyprenylated Acylphloroglucinols from the Flowers of Hypericum monogynum".JOURNAL OF ORGANIC CHEMISTRY 86.10(2021):7021-7027. |
入库方式： OAI收割
来源：昆明植物研究所
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