Polycyclic polyprenylated acylphloroglucinol derivatives with neuroprotective effects from Hypericum monogynum
文献类型：期刊论文
| 作者 | Zeng,Yan-Rong; Li,Ya-Na; Lou,Hua-Yong; Jian,Jun-You; Gu,Wei ; Huang,Lie-Jun; Du,Guan-Hua; Yuan,Chun-Mao; Hao,Xiao-Jiang
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| 刊名 | JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
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| 出版日期 | 2021 |
| 卷号 | 23期号:1页码:73-81 |
| 关键词 | Hypericum monogynum polycyclic polyprenylated acylphloroglucinols (PPAPs) neuroprotective effects structure-activity relationship ST JOHNS WORT PHLOROGLUCINOL DERIVATIVES PRENYLATED PHLOROGLUCINOL HYPERFORIN ANALOGS |
| ISSN号 | 1028-6020 |
| DOI | 10.1080/10286020.2019.1698551 |
| 英文摘要 | A new polycyclic polyprenylated acylphloroglucinol (PPAP), hypermonin C (1), along with nine known PPAPs (2-10) were obtained from the leaves and twigs of Hypericum monogynum. The structures of the isolates were determined on the basis of extensive spectroscopic analysis. The neuroprotective effects of the isolates against several chemical-induced injuries in SH-SY5Y and PC12 cells were assessed, and most of the compounds exhibited significant protective effects at 10 mu g/ml. Especially, three compounds (1, 3, and 7) showed excellent neuroprotective activity with a cell viability of 92.4% similar to 95.8% in KCl-induced SH-SY5Y cell injury. Their preliminary structure-activity relationship was also discussed and the configuration of substituent in furohyperforin may be critical for the neuroprotective activity of PPAP derivatives. |
| WOS记录号 | WOS:000502731100001 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/73102]  |
| 专题 | 中国科学院昆明植物研究所 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 2.Yuan, Chun-Mao 3.Guizhou Med Univ, Coll Basic Med, Guiyang 550004, Guizhou, Peoples R China 4.Guizhou Med Univ, State Key Lab Funct & Applicat Med Plants, Guiyang 550014, Guizhou, Peoples R China 5.[Zeng, Yan-Rong 6.Li, Ya-Na 7.Lou, Hua-Yong 8.Jian, Jun-You 9.Gu, Wei 10.Huang, Lie-Jun |
| 推荐引用方式 GB/T 7714 | Zeng,Yan-Rong,Li,Ya-Na,Lou,Hua-Yong,et al. Polycyclic polyprenylated acylphloroglucinol derivatives with neuroprotective effects from Hypericum monogynum[J]. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,2021,23(1):73-81. |
| APA | Zeng,Yan-Rong.,Li,Ya-Na.,Lou,Hua-Yong.,Jian,Jun-You.,Gu,Wei.,...&Hao,Xiao-Jiang.(2021).Polycyclic polyprenylated acylphloroglucinol derivatives with neuroprotective effects from Hypericum monogynum.JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,23(1),73-81. |
| MLA | Zeng,Yan-Rong,et al."Polycyclic polyprenylated acylphloroglucinol derivatives with neuroprotective effects from Hypericum monogynum".JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH 23.1(2021):73-81. |
入库方式： OAI收割
来源：昆明植物研究所
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