Chemical constituents from the flowers of Hypericum monogynum L. with COX-2 inhibitory activity
文献类型：期刊论文
| 作者 | Li,Ya-Nan; Zeng,Yan-Rong; Yang,Jue; He,Wenwen; Chen,Junlei; Deng,Lulu; Yi,Ping; Huang,Lie-Jun; Gu,Wei ; Hu,Zhan-Xing
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| 刊名 | PHYTOCHEMISTRY
 |
| 出版日期 | 2022 |
| 卷号 | 193页码:112970 |
| 关键词 | Hypericum monogynum L. Hypericaceae Chemical constituents Polycyclic polyprenylated acylphloroglucinols Flavonoids COX-2 inhibitors |
| ISSN号 | 0031-9422 |
| DOI | 10.1016/j.phytochem.2021.112970 |
| 英文摘要 | Hypericum monogynum L. (Hypericaceae) has been used as a folk Chinese medicine for the treatment of in-flammatory related diseases. Cyclooxygenase-2 (COX-2) is a crucial target for the development of agents to treat inflammation. To search for anti-inflammatory compounds from traditional Chinese medicines, a chemical constituent study along with COX-2 inhibitory activity analysis was performed for this plant. In this study, sixteen chemical monomers, including three undescribed oxidative degradation polycyclic polyprenylated acylphloroglucinols (PPAPs, hypemoins C-E), two undescribed PPAPs (hypemoins A and B), and 11 known compounds, were identified from the flowers of H. monogynum. Their structures were characterized by HRESIMS, NMR techniques, ECD, and single crystal X-ray diffraction. Four flavonoid derivatives showed remarkable COX-2 inhibitory activities, with IC50 values ranging from 0.220 +/- 0.006 to 1.655 +/- 0.098 mu M. Among these compounds, the possible recognition mechanism between quercetin 3-(6-O-caffeoyl)-beta-3-D-galactoside and COX-2 was predicted by molecular docking analysis. Moreover, the multidrug resistance reversal activities for the selected compounds were evaluated. |
| WOS记录号 | WOS:000715094900001 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/73103]  |
| 专题 | 中国科学院昆明植物研究所 |
| 作者单位 | 1.Yuan, Chun-Mao 2.[Li, Ya-Nan 3.Zeng, Yan-Rong 4.Yang, Jue 5.He, Wenwen 6.Chen, Junlei 7.Deng, Lulu 8.Yi, Ping 9.Guizhou Med Univ, State Key Lab Funct & Applicat Med Plants, Guiyang 550014, Peoples R China 10.Key Lab Chem Nat Prod Guizhou Prov, Guiyang 550014, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li,Ya-Nan,Zeng,Yan-Rong,Yang,Jue,et al. Chemical constituents from the flowers of Hypericum monogynum L. with COX-2 inhibitory activity[J]. PHYTOCHEMISTRY,2022,193:112970. |
| APA | Li,Ya-Nan.,Zeng,Yan-Rong.,Yang,Jue.,He,Wenwen.,Chen,Junlei.,...&Hao,Xiao-Jiang.(2022).Chemical constituents from the flowers of Hypericum monogynum L. with COX-2 inhibitory activity.PHYTOCHEMISTRY,193,112970. |
| MLA | Li,Ya-Nan,et al."Chemical constituents from the flowers of Hypericum monogynum L. with COX-2 inhibitory activity".PHYTOCHEMISTRY 193(2022):112970. |
入库方式： OAI收割
来源：昆明植物研究所
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