Hypermogins A-D, four highly modified polycyclic polyprenylated acylphloroglucinols from Hypericum monogynum
文献类型：期刊论文
| 作者 | Zeng,Yanrong; Yang,Jue; Li,Yanan; Gu,Wei ; Huang,Liejun; Yi,Ping; Yuan,Chunmao; Hao,Xiaojiang
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| 刊名 | TETRAHEDRON LETTERS
 |
| 出版日期 | 2021 |
| 卷号 | 64页码:152733 |
| ISSN号 | 0040-4039 |
| 关键词 | Hypericum monogynum PPAPs Multidrug resistance reversal activity PHLOROGLUCINOL DERIVATIVES |
| DOI | 10.1016/j.tetlet.2020.152733 |
| 英文摘要 | Four highly modified polycyclic polyprenylated acylphloroglucinols (PPAPs) with an unusual 6,5,5-tricyclic system, hypermogins A-D (1-4), together with one known analogue (5), were isolated from the flowers of Hypericum monogynum. From a possible biogenic synthesis pathway analysis, compounds 2 and 3 could be obtained by oxidation of a double bond and hydrolysis for 1 and 5. In addition, compound 3 might undergo a pinacol rearrangement to produce compound 4. The structures of the isolates were determined by comprehensive MS, NMR spectroscopy and electronic circular dichroism (ECD) calculations. All compounds significantly reversed multidrug resistance in MCF-7/ADR cells. (C) 2020 Elsevier Ltd. All rights reserved. |
| WOS记录号 | WOS:000610242900008 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/73122]  |
| 专题 | 中国科学院昆明植物研究所 |
| 作者单位 | 1.Chinese Acad Sci, Key Lab Phytochem & Plant Resources West China, Kunming Inst Bot, Kunming 650201, Yunnan, Peoples R China 2.Guizhou Med Univ, Sch Basic Med Sci, Guiyang 550025, Peoples R China 3.Guizhou Med Univ, State Key Lab Funct & Applicat Med Plants, Guiyang 550014, Peoples R China 4.Chinese Acad Sci, Key Lab Chem Nat Prod Guizhou Prov, Guiyang 550014, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zeng,Yanrong,Yang,Jue,Li,Yanan,et al. Hypermogins A-D, four highly modified polycyclic polyprenylated acylphloroglucinols from Hypericum monogynum[J]. TETRAHEDRON LETTERS,2021,64:152733. |
| APA | Zeng,Yanrong.,Yang,Jue.,Li,Yanan.,Gu,Wei.,Huang,Liejun.,...&Hao,Xiaojiang.(2021).Hypermogins A-D, four highly modified polycyclic polyprenylated acylphloroglucinols from Hypericum monogynum.TETRAHEDRON LETTERS,64,152733. |
| MLA | Zeng,Yanrong,et al."Hypermogins A-D, four highly modified polycyclic polyprenylated acylphloroglucinols from Hypericum monogynum".TETRAHEDRON LETTERS 64(2021):152733. |
入库方式： OAI收割
来源：昆明植物研究所
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