AmAT19, an acetyltransferase from Astragalus membranaceus, catalyses specific 6 alpha-OH acetylation for tetracyclic triterpenes and steroids
文献类型：期刊论文
| 作者 | Wang,Linlin ; Chen,Kuan; Wang,Zilong; Yi,Yang; Zhang,Meng; Hasan,Aobulikasimu; Kuang,Yi; Shaker,Sharpkate; Yu,Rong; Wang,Haotian
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| 刊名 | ORGANIC & BIOMOLECULAR CHEMISTRY
 |
| 出版日期 | 2021 |
| 卷号 | 19期号:33页码:7186-7189 |
| ISSN号 | 1477-0520 |
| 关键词 | ACYLATION ACYLTRANSFERASE CYCLOASTRAGENOL BAHD |
| DOI | 10.1039/d1ob01106e |
| 英文摘要 | Tetracyclic triterpenes and steroids are pharmacologically important molecules, and acetylation could improve their bioactivities. In this study, a highly regio- and stereo-specific acetyltransferase, AmAT19, was discovered from Astragalus membranaceus. AmAT19 could selectively catalyze the 6 alpha-OH acetylation of four tetracyclic triterpenes and steroids. The strict selectivity is associated with different orientations of the 6 alpha/beta-OH as indicated by molecular docking. Acetylated products 1a, 3a and 4a remarkably increased the inhibitory activity against the 3-chymotrypsin-like protease (3CL(pro)) of SARS-CoV-2, compared to 1, 3, and 4. AmAT19 could be a promising catalyst for specific 6 alpha-OH acetylation to expand the molecular diversity of triterpenes and steroids. |
| WOS记录号 | WOS:000683435600001 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/73123]  |
| 专题 | 中国科学院昆明植物研究所 |
| 作者单位 | 1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, 38 Xueyuan Rd, Beijing 100191, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang,Linlin,Chen,Kuan,Wang,Zilong,et al. AmAT19, an acetyltransferase from Astragalus membranaceus, catalyses specific 6 alpha-OH acetylation for tetracyclic triterpenes and steroids[J]. ORGANIC & BIOMOLECULAR CHEMISTRY,2021,19(33):7186-7189. |
| APA | Wang,Linlin.,Chen,Kuan.,Wang,Zilong.,Yi,Yang.,Zhang,Meng.,...&Qiao,Xue.(2021).AmAT19, an acetyltransferase from Astragalus membranaceus, catalyses specific 6 alpha-OH acetylation for tetracyclic triterpenes and steroids.ORGANIC & BIOMOLECULAR CHEMISTRY,19(33),7186-7189. |
| MLA | Wang,Linlin,et al."AmAT19, an acetyltransferase from Astragalus membranaceus, catalyses specific 6 alpha-OH acetylation for tetracyclic triterpenes and steroids".ORGANIC & BIOMOLECULAR CHEMISTRY 19.33(2021):7186-7189. |
入库方式： OAI收割
来源：昆明植物研究所
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