Traditional Chinese medicine compound, Bu Sheng Hui Yang Fang, promotes the proliferation of lymphocytes in the immunosuppressed mice potentially by upregulating IL-4 signaling
文献类型：期刊论文
| 作者 | Wang,Yajie; Tan,Jiabin; Hu,Peng; Pei,Qiang; Wen,Yan; Ma,Wenqing; Shi,Keqian; Li,Zengzheng; Li,Huiyuan; Cheng,Fengyu |
| 刊名 | BIOMEDICINE & PHARMACOTHERAPY
 |
| 出版日期 | 2021 |
| 卷号 | 134页码:111107 |
| 关键词 | Bu Shen Hui Yang Fang (BSHY) Immunoenhancement Lymphocytes Proliferation Cytokine IL-4 ACUTE MYELOID-LEUKEMIA IMMUNE-SYSTEM CANCER CELLS IMMUNOSURVEILLANCE EXPRESSION |
| ISSN号 | 0753-3322 |
| DOI | 10.1016/j.biopha.2020.111107 |
| 英文摘要 | The immune system plays a pivotal role in defending against infection and cancer immunosurveillance during the onset and procession of malignant disease. Cancer patients are frequently immunocompromised and subject to refractory infection and relapse of leukemia, due to the cytotoxic agents and immunosuppressive glucocorticoids in the chemotherapy regimens. Bu Shen Hui Yang Fang (BSHY), a traditional Chinese compound, was widely used in China to enhance the immune system of leukemia patients combined with chemotherapy and effectively lowered their risk of infection, with specific mechanism unknown yet. Thus, we investigated the effects of BSHY on the immune system using immunosuppressive mouse models. By analyzing the immune system of immuno-suppressed BALB/C mice induced by hydrocortisone, we found an increase of CD4(+) and CD8(+) lymphocytes in the spleens of mice after BSHY treatment. Furthermore, we found the enhanced immune system in BSHY treated group was due to increased proliferation and decreased apoptosis of lymphocytes. Cytokine array analysis revealed that interleukin 4 (IL-4) was reduced in the plasma of immunosuppressed mice but returned to a normal level after BSHY treatment. Moreover, we found IL-4 was an adverse prognostic factor in acute myeloid leukemia patients and part of them could be elevated by BSHY. Mechanistically, we found BSHY enhances the proliferation of lymphocytes in a Stat6-dependent manner. In summary, our current study demonstrates that BSHY enhances the proliferation of lymphocytes in the immunosuppressed mice via upregulating IL-4 signaling. |
| WOS记录号 | WOS:000611822700004 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/73149]  |
| 专题 | 中国科学院昆明植物研究所 |
| 作者单位 | 1.Yunnan Blood Dis Hosp, Peoples Hosp Yunnan Prov 1, Yunnan Blood Dis Clin Med Ctr, Natl Key Clin Specialty Hematol,Dept Hematol, Kunming, Yunnan, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Yunnan, Peoples R China 3.Kunming Univ Sci & Technol, Kunming, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang,Yajie,Tan,Jiabin,Hu,Peng,et al. Traditional Chinese medicine compound, Bu Sheng Hui Yang Fang, promotes the proliferation of lymphocytes in the immunosuppressed mice potentially by upregulating IL-4 signaling[J]. BIOMEDICINE & PHARMACOTHERAPY,2021,134:111107. |
| APA | Wang,Yajie.,Tan,Jiabin.,Hu,Peng.,Pei,Qiang.,Wen,Yan.,...&Yang,Tonghua.(2021).Traditional Chinese medicine compound, Bu Sheng Hui Yang Fang, promotes the proliferation of lymphocytes in the immunosuppressed mice potentially by upregulating IL-4 signaling.BIOMEDICINE & PHARMACOTHERAPY,134,111107. |
| MLA | Wang,Yajie,et al."Traditional Chinese medicine compound, Bu Sheng Hui Yang Fang, promotes the proliferation of lymphocytes in the immunosuppressed mice potentially by upregulating IL-4 signaling".BIOMEDICINE & PHARMACOTHERAPY 134(2021):111107. |
入库方式： OAI收割
来源：昆明植物研究所
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