A New World Monkey Resembles Human in Bitter Taste Receptor Evolution and Function via a Single Parallel Amino Acid Substitution
文献类型：期刊论文
| 作者 | Yang,Hui; Yang,Songlin; Fan,Fei; Li,Yun; Dai,Shaoxing; Zhou,Xin; Steiner,Cynthia C.; Coppedge,Bretton; Roos,Christian; Cai,Xianghai
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| 刊名 | MOLECULAR BIOLOGY AND EVOLUTION
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| 出版日期 | 2021 |
| 卷号 | 38期号:12页码:5472-5479 |
| 关键词 | convergent evolution bitter taste receptors Tas2R16 human white-faced saki Pithecia pithecia adaptive evolution PHYLOGENETIC ANALYSIS SENSITIVITY DIVERSITY SELECTION TAS2R16 OPTIMIZATION CONVERGENT PLATFORM DOCKING FAMILY |
| ISSN号 | 0737-4038 |
| DOI | 10.1093/molbev/msab263 |
| 英文摘要 | Bitter taste receptors serve as a vital component in the defense system against toxin intake by animals, and the family of genes encoding these receptors has been demonstrated, usually by family size variance, to correlate with dietary preference. However, few systematic studies of specific Tas2R to unveil their functional evolution have been conducted. Here, we surveyed Tas2R16 across all major clades of primates and reported a rare case of a convergent change to increase sensitivity to beta-glucopyranosides in human and a New World monkey, the white-faced saki. Combining analyses at multiple levels, we demonstrate that a parallel amino acid substitution (K172N) shared by these two species is responsible for this functional convergence of Tas2R16. Considering the specialized feeding preference of the white-faced saki, the K172N change likely played an important adaptive role in its early evolution to avoid potentially toxic cyanogenic glycosides, as suggested for the human TAS2R16 gene. |
| WOS记录号 | WOS:000741368600017 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/73162]  |
| 专题 | 中国科学院昆明植物研究所 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources We, Kunming, Yunnan, Peoples R China 2.Chinese Acad Sci, Ctr Excellence Anim Evolut & Genet, Kunming, Yunnan, Peoples R China 3.Chinese Acad Sci, Kunming Inst Zool, State Key Lab Genet Resources & Evolut, Kunming, Yunnan, Peoples R China 4.Univ Chinese Acad Sci, Coll Life Sci, Beijing, Peoples R China 5.Beckman Ctr Conservat Res, San Diego Zoo Wildlife Alliance, Escondido, CA USA 6.Leibniz Inst Primate Res, German Primate Ctr, Gene Bank Primates & Primate Genet Lab, Gottingen, Germany 7.Irwin, David M.] Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON, Canada |
| 推荐引用方式 GB/T 7714 | Yang,Hui,Yang,Songlin,Fan,Fei,et al. A New World Monkey Resembles Human in Bitter Taste Receptor Evolution and Function via a Single Parallel Amino Acid Substitution[J]. MOLECULAR BIOLOGY AND EVOLUTION,2021,38(12):5472-5479. |
| APA | Yang,Hui.,Yang,Songlin.,Fan,Fei.,Li,Yun.,Dai,Shaoxing.,...&Shi,Peng.(2021).A New World Monkey Resembles Human in Bitter Taste Receptor Evolution and Function via a Single Parallel Amino Acid Substitution.MOLECULAR BIOLOGY AND EVOLUTION,38(12),5472-5479. |
| MLA | Yang,Hui,et al."A New World Monkey Resembles Human in Bitter Taste Receptor Evolution and Function via a Single Parallel Amino Acid Substitution".MOLECULAR BIOLOGY AND EVOLUTION 38.12(2021):5472-5479. |
入库方式： OAI收割
来源：昆明植物研究所
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