Structurally diverse limonoids and bio-active evaluation from Trichilia connaroides
文献类型：期刊论文
| 作者 | Cao,Dong-Hua; Yao,Jian-Neng; Sun,Peng; Ji,Kai-Long; Li,Xiao-Nian; Cai,Qiang; Xiao,Chun-Fen; Hu,Hua-Bin; Yu,Zhi-Yong; Xu,You-Kai |
| 刊名 | FITOTERAPIA
 |
| 出版日期 | 2021 |
| 卷号 | 153页码:105001 |
| 关键词 | Trichilia connaroides Meliaceae Limonoid Cytotoxicity Anti-inflammatory NITRIC-OXIDE PRODUCTION CHEMICAL-CONSTITUENTS CARBON SKELETON RECENT PROGRESS TETRANORTRITERPENOIDS LEAVES SEEDS CHEMISTRY STEROIDS TWIGS |
| ISSN号 | 0367-326X |
| DOI | 10.1016/j.fitote.2021.105001 |
| 英文摘要 | Four new limonoids, named as trichiconlide G (1), 2-hydroxyltrijugin F (2), 23-oxo-21-hydroxyltrijugin F (3), 21-oxo-23-hydroxyltrijugin F (4), along with sixteen known analogues (5-20) were isolated from the leaves and twigs of Trichilia connaroides. Their structures and absolute configurations were determined by spectroscopic analyses, X-ray diffraction analysis, and TD-DFT-ECD calculations. Trichiconlide G (1) is one rare naturally occurring 1,2-seco phragmalin-type limonoid bearing a C-7/28 delta-lactone ring. Additionally, 2-hydroxyltrijugin F (2), 23-oxo-21-hydroxyltrijugin F (3), and 21-oxo-23-hydroxyltrijugin F (4) are three naturally occurring limonoids with a rare C-16/8 delta-lactone ring. All isolates were evaluated for their cytotoxic and anti-inflammatory activities. None of compounds exhibited cytotoxicity against five human cancer cell lines A-549, HepG2, 5-8F, Siha, and SCC-4 at the concentration of 40 mu M. Compounds 16 and 17 showed moderate anti-inflammatory activity with IC50 values of 28.45 +/- 2.51 and 22.66 +/- 2.01 mu M, respectively. |
| WOS记录号 | WOS:000684837300008 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/73169]  |
| 专题 | 中国科学院昆明植物研究所 |
| 作者单位 | 1.Chinese Acad Sci, Key Lab Trop Plant Resources & Sustainable Use, Xishuangbanna Trop Bot Garden, Menglun 666303, Peoples R China 2.Hu, Hua-Bin 3.[Yao, Jian-Neng 4.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China 5.[Cai, Qiang 6.Univ South China, Affiliated Changsha Cent Hosp, Hengyang Med Sch, Changsha 410004, Peoples R China 7.Second Peoples Hosp Yunnan Prov, Dept Hepatobiliary Surg, Kunming 650021, Peoples R China 8.[Cao, Dong-Hua 9.Sun, Peng 10.Ji, Kai-Long |
| 推荐引用方式 GB/T 7714 | Cao,Dong-Hua,Yao,Jian-Neng,Sun,Peng,et al. Structurally diverse limonoids and bio-active evaluation from Trichilia connaroides[J]. FITOTERAPIA,2021,153:105001. |
| APA | Cao,Dong-Hua.,Yao,Jian-Neng.,Sun,Peng.,Ji,Kai-Long.,Li,Xiao-Nian.,...&Xu,You-Kai.(2021).Structurally diverse limonoids and bio-active evaluation from Trichilia connaroides.FITOTERAPIA,153,105001. |
| MLA | Cao,Dong-Hua,et al."Structurally diverse limonoids and bio-active evaluation from Trichilia connaroides".FITOTERAPIA 153(2021):105001. |
入库方式： OAI收割
来源：昆明植物研究所
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