FPR2-based anti-inflammatory and anti-lipogenesis activities of novel meroterpenoid dimers from Ganoderma
文献类型：期刊论文
| 作者 | Peng,Xing-Rong; Wang,Qian; Wang,Hui-Rong; Hu,Kun ; Xiong,Wen-Yong; Qiu,Ming-Hua
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| 刊名 | BIOORGANIC CHEMISTRY
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| 出版日期 | 2021 |
| 卷号 | 116页码:105338 |
| 关键词 | Ganoderma applanatum Meroterpenoid dimers Molecular docking Anti-lipogenesis FPR2-based inflammation INDUCED INSULIN-RESISTANCE ADIPOCYTE DIFFERENTIATION OBESITY INFLAMMATION DEFICIENCY MACROPHAGES ACTIVATION EXPRESSION LIGAND MICE |
| ISSN号 | 0045-2068 |
| DOI | 10.1016/j.bioorg.2021.105338 |
| 英文摘要 | Four pairs of novel meroterpenoid dimers, (+/-)-applandimeric acids A-D (1-4) with an unprecedented spiro[furo [3,2-b]benzofuran-3,2 '-indene] core were isolated from the fruiting bodies of Ganoderma applanatum. Their planar structures were unambiguously determined via extensive spectroscopic analysis. Their relative and absolute configurations were confirmed through calculated internuclear distance, coupling constant, 13C NMR with DP4 + analysis and electronic circular dichroism (ECD). Furthermore, the molecular docking-based method was used to evaluate their interaction with formyl peptide receptor 2 (FPR2) associated with inflammation. Interestingly, (+/-)-applandimeric acid D (4) can bond with FPR2 by some key hydrogen bonds. Furthermore, an in vitro bioassay verified that 4 can inhibit the expression of FPR2 with IC50 value of 7.93 mu M. In addition, compared to the positive control LiCl (20 mM), 4 showed comparable anti-lipogenesis activity at the concentration of 20 mu M. Meanwhile, 4 can suppress the protein levels of peroxisome proliferators-activated receptor-gamma (PPAR-gamma), CCAAT/ enhancer-binding protein-fl (C/EBP-fl), adipocyte fatty acid-binding protein 4 (FABP4), and fatty acid synthase (FAS) through activating AMP-activated protein kinase (AMPK) signaling pathway. Thus, our findings indicate that compound 4 could be a lead compound to treat obesity and obesity-related diseases by inhibiting lipid accumulation in adipocyte and alleviating inflammation. |
| WOS记录号 | WOS:000702879500011 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/73187]  |
| 专题 | 中国科学院昆明植物研究所 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 2.Southern Univ Sci & Technol, Dept Biol, Shenzhen, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Peng,Xing-Rong,Wang,Qian,Wang,Hui-Rong,et al. FPR2-based anti-inflammatory and anti-lipogenesis activities of novel meroterpenoid dimers from Ganoderma[J]. BIOORGANIC CHEMISTRY,2021,116:105338. |
| APA | Peng,Xing-Rong,Wang,Qian,Wang,Hui-Rong,Hu,Kun,Xiong,Wen-Yong,&Qiu,Ming-Hua.(2021).FPR2-based anti-inflammatory and anti-lipogenesis activities of novel meroterpenoid dimers from Ganoderma.BIOORGANIC CHEMISTRY,116,105338. |
| MLA | Peng,Xing-Rong,et al."FPR2-based anti-inflammatory and anti-lipogenesis activities of novel meroterpenoid dimers from Ganoderma".BIOORGANIC CHEMISTRY 116(2021):105338. |
入库方式： OAI收割
来源：昆明植物研究所
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