Neo-clerodane Diterpenoids with Hypoglycemic Effects in Vivo from the Aerial Parts of Salvia hispanica L.
文献类型：期刊论文
| 作者 | Fan,Min ; Wang,Ting; Peng,Li-Yan; Huang,Jun-Shang; Wu,Xing-De; Wang,He-Yao; Zhao,Qin-Shi
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| 刊名 | CHEMISTRY & BIODIVERSITY
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| 出版日期 | 2021 |
| 卷号 | 18期号:9页码:e2100517 |
| 关键词 | Salvia hispanica neo-clerodane diterpenoid salvihispin H type 2 diabetes mellitus GLUCOSE-TOLERANCE RISK-FACTORS THERAPY |
| ISSN号 | 1612-1872 |
| DOI | 10.1002/cbdv.202100517 |
| 英文摘要 | A new neo-clerodane diterpenoid, salvihispin H (1), and six known ones (2-7) were identified from the aerial parts of Salvia hispanica L. The structure and absolute configuration of 1 were elucidated by extensive analysis of spectroscopic (H-1, C-13, and 2D NMR, and HR-ESI-MS) and single-crystal X-ray diffraction data. The anti-diabetic effects of salvihispin H (1) and salvifaricin (2) were evaluated in diabetic db/db mice. The data showed that 1 and 2 could significantly reduce fasting blood glucose level and improve insulin resistance, and compound 1 exerted glucose-lowering effect more quickly than metformin. In addition, 1 and 2 could also reduce serum TG level in db/db mice. These results demonstrated that compounds 1 and 2 could be considered as potent candidates for the therapy of type 2 diabetes mellitus (T2DM). |
| WOS记录号 | WOS:000680807100001 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/73202]  |
| 专题 | 中国科学院昆明植物研究所 |
| 作者单位 | 1.Dali Univ, Coll Pharm, Dali 671000, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Yunnan, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Fan,Min,Wang,Ting,Peng,Li-Yan,et al. Neo-clerodane Diterpenoids with Hypoglycemic Effects in Vivo from the Aerial Parts of Salvia hispanica L.[J]. CHEMISTRY & BIODIVERSITY,2021,18(9):e2100517. |
| APA | Fan,Min.,Wang,Ting.,Peng,Li-Yan.,Huang,Jun-Shang.,Wu,Xing-De.,...&Zhao,Qin-Shi.(2021).Neo-clerodane Diterpenoids with Hypoglycemic Effects in Vivo from the Aerial Parts of Salvia hispanica L..CHEMISTRY & BIODIVERSITY,18(9),e2100517. |
| MLA | Fan,Min,et al."Neo-clerodane Diterpenoids with Hypoglycemic Effects in Vivo from the Aerial Parts of Salvia hispanica L.".CHEMISTRY & BIODIVERSITY 18.9(2021):e2100517. |
入库方式： OAI收割
来源：昆明植物研究所
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