Tetranorlanostane and Lanostane Triterpenoids with Cytotoxic Activity from the Epidermis of Poria cocos
文献类型：期刊论文
| 作者 | Jiang,Ting-Ting; Ding,Lin-Fen; Nie,Wei; Wang,Liu-Yan; Lei,Tie; Wu,Xing-De; Zhao,Qin-Shi |
| 刊名 | CHEMISTRY & BIODIVERSITY
 |
| 出版日期 | 2021 |
| 卷号 | 18期号:5 |
| 关键词 | Poria cocos lanostane triterpenoid tetranorlanostane triterpenoid cytotoxic activity SURFACE-LAYER EXTRACTS |
| ISSN号 | 1612-1872 |
| DOI | 10.1002/cbdv.202100196 |
| 英文摘要 | Two unprecedented tetranorlanostane triterpenoids, poricolides A (1) and B (2), and two new lanostane triterpenoids, 3 beta-acetoxy-24-methyllanosta-8,16,24(31)-trien-21-oic acid (3) and 3 beta-acetoxylanosta-7,9(11),16,23-tetraen-21-oic acid (4), were isolated from the epidermis of Poria cocos. The structures of 1-4 were determined via analysis of H-1-, C-13-, and 2D-NMR, and HR-ESI-MS data, and the absolute configurations of 1 and 3 were established by single-crystal X-ray diffraction analysis. Compounds 1 and 2 were the first report of tetranorlanostane triterpenoid having a delta-lactone ring at C(17). Compounds 3 and 4 were rare lanostane triterpenoids having a double bond between C(16) and C(17). Compounds 1-4 exhibited potent antiproliferative effects against A549, SMMC-7721, MCF-7, and SW480 cancer cell lines with IC50 values from 16.19 +/- 0.38 to 27.74 +/- 1.12 mu M. |
| WOS记录号 | WOS:000642321800001 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/73205]  |
| 专题 | 中国科学院昆明植物研究所 |
| 作者单位 | 1.Kunming Med Univ, Sch Pharmaceut Sci, Kunming 650500, Yunnan, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 3.Kunming Med Univ, Yunnan Key Lab Pharmacol Nat Prod, Kunming 650500, Yunnan, Peoples R China 4.[Jiang, Ting-Ting 5.Ding, Lin-Fen 6.Nie, Wei 7.Wang, Liu-Yan 8.Lei, Tie 9.Wu, Xing-De |
| 推荐引用方式 GB/T 7714 | Jiang,Ting-Ting,Ding,Lin-Fen,Nie,Wei,et al. Tetranorlanostane and Lanostane Triterpenoids with Cytotoxic Activity from the Epidermis of Poria cocos[J]. CHEMISTRY & BIODIVERSITY,2021,18(5). |
| APA | Jiang,Ting-Ting.,Ding,Lin-Fen.,Nie,Wei.,Wang,Liu-Yan.,Lei,Tie.,...&Zhao,Qin-Shi.(2021).Tetranorlanostane and Lanostane Triterpenoids with Cytotoxic Activity from the Epidermis of Poria cocos.CHEMISTRY & BIODIVERSITY,18(5). |
| MLA | Jiang,Ting-Ting,et al."Tetranorlanostane and Lanostane Triterpenoids with Cytotoxic Activity from the Epidermis of Poria cocos".CHEMISTRY & BIODIVERSITY 18.5(2021). |
入库方式： OAI收割
来源：昆明植物研究所
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