Nematicidal activity of tirotundin and parthenolide isolated from Tithonia diversifolia and Chrysanthemum parthenium
文献类型：期刊论文
| 作者 | Lan,Mingxian; Gao,Xi; Duan,Xiuan; Li,Hongmei; Yu,Hang; Li,Jinliang; Zhao,Yueqin; Hao,Xiaojiang ; Zhao,Yuhan; Ding,Xiao
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| 刊名 | JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART B-PESTICIDES FOOD CONTAMINANTS AND AGRICULTURAL WASTES
 |
| 出版日期 | 2021 |
| ISSN号 | 0360-1234 |
| 关键词 | Parthenolide tirotundin acetylcholinesterase enzyme kinetics toxic effects SESQUITERPENE LACTONE ANTICANCER FLAVONOIDS EXTRACT ANALOG |
| DOI | 10.1080/03601234.2021.2022945 |
| 英文摘要 | Acetylcholinesterase (AChE) is an enzyme that catalyzes acetylcholine into choline and acetic acid. Conventional pesticides, including organophosphates and carbamates target and inhibit the activity of AChE. To obtain more pesticide precursors that meet the safety requirements, more than 200 compounds were screened. Tirotundin and parthenolide identified as potential neurotoxins to nematodes were isolated from Tithonia diversifolia and Chrysanthemum parthenium, respectively. Their IC50 values were 6.89 +/- 0.30 and 5.51 +/- 0.23 mu g/mL, respectively against the AChE isolated from Caenorhabditis elegans. AChE was inhibited in a dose-dependent manner using the two compounds. And the Lineweaver-Burk and Dixon plots indicated that tirotundin and parthenolide were reversible inhibitors against AChE, both inhibiting AChE in a mixed-type competitive manner and demonstrating these compounds may possess dual binding site AChE inhibitors. LC50 values of tirotundin and parthenolide against C. elegans were 9.16 +/- 0.21 and 7.23 +/- 0.48 mu g/mL, respectively. These results provide a certain theoretical basis for the development and utilization of novel pesticides. |
| WOS记录号 | WOS:000739127300001 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/73213]  |
| 专题 | 中国科学院昆明植物研究所 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 2.Yunnan Agr Univ, State Key Lab Conservat & Utilizat Bioresources Y, Kunming 650100, Yunnan, Peoples R China 3.Green Dev Ctr Baoshan City, Agroenvironm Monitoring Ctr Baoshan City, Baoshan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lan,Mingxian,Gao,Xi,Duan,Xiuan,et al. Nematicidal activity of tirotundin and parthenolide isolated from Tithonia diversifolia and Chrysanthemum parthenium[J]. JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART B-PESTICIDES FOOD CONTAMINANTS AND AGRICULTURAL WASTES,2021. |
| APA | Lan,Mingxian.,Gao,Xi.,Duan,Xiuan.,Li,Hongmei.,Yu,Hang.,...&Wu,Guoxing.(2021).Nematicidal activity of tirotundin and parthenolide isolated from Tithonia diversifolia and Chrysanthemum parthenium.JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART B-PESTICIDES FOOD CONTAMINANTS AND AGRICULTURAL WASTES. |
| MLA | Lan,Mingxian,et al."Nematicidal activity of tirotundin and parthenolide isolated from Tithonia diversifolia and Chrysanthemum parthenium".JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART B-PESTICIDES FOOD CONTAMINANTS AND AGRICULTURAL WASTES (2021). |
入库方式： OAI收割
来源：昆明植物研究所
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