Asymmetric Total Synthesis of (+)-Quinocarcinamide
文献类型：期刊论文
| 作者 | Li,Lei; Shi,Li; Wei,Kun; Yang,Yu-Rong |
| 刊名 | ORGANIC LETTERS
 |
| 出版日期 | 2021 |
| 卷号 | 23期号:20页码:7972-7975 |
| 关键词 | PRIMARY ALLYLIC AMINES (-)-QUINOCARCIN CYCLOADDITION SUBSTITUTION CONDENSATION QUINOCARCIN ALCOHOLS ACID |
| ISSN号 | 1523-7060 |
| DOI | 10.1021/acs.orglett.1c02970 |
| 英文摘要 | The first asymmetric total synthesis of (+)-quinocarcinamide (3), an enantiomer of the natural oxidation product from antitumor antibiotic (-)-quinocarcin (1), is described. Key steps include an iridium-catalyzed asymmetric allylic amidation of racemic alcohol 9, olefin cross-metathesis followed by a S(N)2' to forge tetrahydroisoquinoline, and stereocontrolled 1,3-dipolar cycloaddition between a facilely generated azomethine ylide and tert-butyl acrylate to construct the diazabicyclo[3.2.1]octane ring. |
| WOS记录号 | WOS:000709693500053 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/73223]  |
| 专题 | 中国科学院昆明植物研究所 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li,Lei,Shi,Li,Wei,Kun,et al. Asymmetric Total Synthesis of (+)-Quinocarcinamide[J]. ORGANIC LETTERS,2021,23(20):7972-7975. |
| APA | Li,Lei,Shi,Li,Wei,Kun,&Yang,Yu-Rong.(2021).Asymmetric Total Synthesis of (+)-Quinocarcinamide.ORGANIC LETTERS,23(20),7972-7975. |
| MLA | Li,Lei,et al."Asymmetric Total Synthesis of (+)-Quinocarcinamide".ORGANIC LETTERS 23.20(2021):7972-7975. |
入库方式： OAI收割
来源：昆明植物研究所
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