Synthesis, antitumor activity, and molecular docking of (-)-epigallocatechin-3-gallate-4 beta-triazolopodophyllotoxin conjugates
文献类型：期刊论文
| 作者 | Zi,Cheng-Ting; Yang,Liu; Hu,Yue; Zhang,Pan; Tang,Han; Zhang,Bang-Lei; Shen,Xiao-Jing; Kong,Qing-Hua; Wang,Ya; Wang,Xuan-Jun |
| 刊名 | JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
 |
| 出版日期 | 2021 |
| 卷号 | 23期号:8页码:772-780 |
| ISSN号 | 1028-6020 |
| 关键词 | Podophyllotixin EGCG click reaction antitumor activity molecular docking PODOPHYLLOTOXIN DERIVATIVES CONGENERS |
| DOI | 10.1080/10286020.2020.1786066 |
| 英文摘要 | Two new (-)-epigallocatechin-3-gallate-4 beta-triazolopodophyllotoxin conjugates (7and8) were synthesized and evaluated for biological activity. Compound8showed highly potent anticancer activity against A-549 cell line with IC(50)of 2.16 +/- 1.02 mu M, which displayed the highest selectivity index value (SI = 14.5) in A-549 cells. Molecular docking indicated that compound8could bind with the active site of Top-II. Therefore, compound8might be a promising candidate for further development. |
| WOS记录号 | WOS:000546364300001 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/73241]  |
| 专题 | 中国科学院昆明植物研究所 |
| 作者单位 | 1.[Zi, Cheng-Ting 2.Hu, Yue 3.Zhang, Pan 4.Tang, Han 5.Zhang, Bang-Lei 6.Wang, Ya 7.Wang, Xuan-Jun 8.Yunnan Agr Univ, Key Lab Pu Er Tea Sci, Minist Educ, Kunming 650201, Yunnan, Peoples R China 9.Yunnan Agr Univ, Coll Sci, Kunming 650201, Yunnan, Peoples R China 10.Shen, Xiao-Jing |
| 推荐引用方式 GB/T 7714 | Zi,Cheng-Ting,Yang,Liu,Hu,Yue,et al. Synthesis, antitumor activity, and molecular docking of (-)-epigallocatechin-3-gallate-4 beta-triazolopodophyllotoxin conjugates[J]. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,2021,23(8):772-780. |
| APA | Zi,Cheng-Ting.,Yang,Liu.,Hu,Yue.,Zhang,Pan.,Tang,Han.,...&Sheng,Jun.(2021).Synthesis, antitumor activity, and molecular docking of (-)-epigallocatechin-3-gallate-4 beta-triazolopodophyllotoxin conjugates.JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,23(8),772-780. |
| MLA | Zi,Cheng-Ting,et al."Synthesis, antitumor activity, and molecular docking of (-)-epigallocatechin-3-gallate-4 beta-triazolopodophyllotoxin conjugates".JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH 23.8(2021):772-780. |
入库方式： OAI收割
来源：昆明植物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。