Resorcylic Acid Lactones Produced by an Endophytic Penicillium ochrochloron Strain from Kadsura angustifolia
文献类型：期刊论文
| 作者 | Song,Hong Chuan; Qin,Dan; Liu,Hai Yang; Dong,Jin Yan; You,Chuan; Wang,Yu Meng |
| 刊名 | PLANTA MEDICA
 |
| 出版日期 | 2021 |
| 卷号 | 87期号:3页码:225-235 |
| 关键词 | Kadsura angustifolia Schisandraceae resorcylic acid lactones Penicillium ochrochloron cytotoxity antibacterial activity FUNGAL METABOLITES HYPOTHEMYCIN STEREOCHEMISTRY ZEARALENONE MACROLIDES PATHWAY CELLS |
| ISSN号 | 0032-0943 |
| DOI | 10.1055/a-1326-2600 |
| 英文摘要 | Four new beta -resorcylic acid lactones, including penochrochlactone A ( 2 ), 4-O-desmethyl-aigialomycin B ( 4 ), and penochrochlactones C and D ( 5 and 6 ), two compounds isolated from a natural source for the first time, 5 alpha , 6 beta -acetonide-aigialomycin B ( 1 ) and penochrochlactone B ( 3 ), together with six known compounds, aigialomycin F ( 7 ), aigialomycins A, B, and D ( 8 - 10 ), zeaenol ( 11 ), and oxozeaenol ( 12 ), were isolated from a mycelial solid culture of the endophytic fungus Penicillium ochrochloron SWUKD4.1850 from the medicinal plant Kadsura angustifolia by sequential purification over silica gel, Sephadex LH-20 column chromatography, and preparative HPLC. Their structures were elucidated by extensive spectroscopic analysis and chemical conversions. In addition, all the new compounds were evaluated for their cytotoxic and antibacterial activities in vitro . Penochrochlactone C ( 5 ) displayed moderate cytotoxicity against the HeLa tumor cell line with an IC (50) value of 9.70 mu M. In the antibacterial assays, compounds 4 - 6 exhibited moderate activities against Staphylococcus aureus, Bacillus subtilis, Escherichia coli , and Pseudomonas aeruginosa with MIC values between 9.7 and 32.0 mu g/mL. |
| WOS记录号 | WOS:000600588300002 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/73313]  |
| 专题 | 中国科学院昆明植物研究所 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Yunnan, Peoples R China 2.Southwest Univ, Sch Life Sci, Minist Educ, Key Lab Ecoenvironm Three Gorges Reservoir Reg, Chongqing, Peoples R China 3.Yunnan Normal Univ, Sch Energy & Environm Sci, 2 Cuihu North Rd, Kunming 650092, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Song,Hong Chuan,Qin,Dan,Liu,Hai Yang,et al. Resorcylic Acid Lactones Produced by an Endophytic Penicillium ochrochloron Strain from Kadsura angustifolia[J]. PLANTA MEDICA,2021,87(3):225-235. |
| APA | Song,Hong Chuan,Qin,Dan,Liu,Hai Yang,Dong,Jin Yan,You,Chuan,&Wang,Yu Meng.(2021).Resorcylic Acid Lactones Produced by an Endophytic Penicillium ochrochloron Strain from Kadsura angustifolia.PLANTA MEDICA,87(3),225-235. |
| MLA | Song,Hong Chuan,et al."Resorcylic Acid Lactones Produced by an Endophytic Penicillium ochrochloron Strain from Kadsura angustifolia".PLANTA MEDICA 87.3(2021):225-235. |
入库方式： OAI收割
来源：昆明植物研究所
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