Lepithiohydimerins A-D: Four Pairs of Neuroprotective Thiohydantoin Dimers Bearing a Disulfide Bond from Maca (Lepidium meyenii Walp.)
文献类型：期刊论文
| 作者 | Peng,Xing-Rong; Zhang,Ran-Ran; Liu,Jun-Hong; Li,Zhong-Rong; Zhou,Lin; Qiu,Ming-Hua
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| 刊名 | CHINESE JOURNAL OF CHEMISTRY
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| 出版日期 | 2021 |
| 卷号 | 39期号:10页码:2738-2744 |
| 关键词 | Lepidium meyenii Walp Thiohydantoin dimers Natural products Structure elucidation Biological activity STRUCTURAL ELUCIDATION DERIVATIVES ANTIOXIDANT HYDANTOIN |
| ISSN号 | 1001-604X |
| DOI | 10.1002/cjoc.202100353 |
| 英文摘要 | Main observation and conclusionAn HPLC-UV-guided separation was performed and four pairs of unprecedented macathiohydantoin dimers, lepithiohydimerins A-D (1-4) bearing a rare disulfide bond were isolated from the tubers of Maca. Their structures were unambiguously confirmed by NMR spectroscopic, X-ray crystallographic and electronic circular dichroism (ECD) analyses. At the concentration of 20 mu mol/L, compounds 2-1, 2-2, and 4-1 increased the viability of PC12 cells with the cell viability at (72.06 +/- 1.14)%, (72.64 +/- 1.49)%, and (70.93 +/- 1.22)%, respectively. Furthermore, the serial concentration experiment showed that they can protect PC12 cells in a dose-dependent manner. |
| WOS记录号 | WOS:000681331200001 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/73333]  |
| 专题 | 中国科学院昆明植物研究所 |
| 作者单位 | 1.Liu, Jun-Hong 2.[Peng, Xing-Rong 3.Zhang, Ran-Ran 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 5.[Zhang, Ran-Ran 6.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West Ch, Kunming Inst Bot, Kunming 650201, Yunnan, Peoples R China 7.Zhou, Lin 8.Li, Zhong-Rong |
| 推荐引用方式 GB/T 7714 | Peng,Xing-Rong,Zhang,Ran-Ran,Liu,Jun-Hong,et al. Lepithiohydimerins A-D: Four Pairs of Neuroprotective Thiohydantoin Dimers Bearing a Disulfide Bond from Maca (Lepidium meyenii Walp.)[J]. CHINESE JOURNAL OF CHEMISTRY,2021,39(10):2738-2744. |
| APA | Peng,Xing-Rong,Zhang,Ran-Ran,Liu,Jun-Hong,Li,Zhong-Rong,Zhou,Lin,&Qiu,Ming-Hua.(2021).Lepithiohydimerins A-D: Four Pairs of Neuroprotective Thiohydantoin Dimers Bearing a Disulfide Bond from Maca (Lepidium meyenii Walp.).CHINESE JOURNAL OF CHEMISTRY,39(10),2738-2744. |
| MLA | Peng,Xing-Rong,et al."Lepithiohydimerins A-D: Four Pairs of Neuroprotective Thiohydantoin Dimers Bearing a Disulfide Bond from Maca (Lepidium meyenii Walp.)".CHINESE JOURNAL OF CHEMISTRY 39.10(2021):2738-2744. |
入库方式： OAI收割
来源：昆明植物研究所
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