Bitter Melon and Diabetes Mellitus
文献类型：期刊论文
| 作者 | Gao,Ya; Li,Xian; Huang,Yanjie; Chen,Jianchao; Qiu,Minghua
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| 刊名 | FOOD REVIEWS INTERNATIONAL
 |
| 出版日期 | 2021 |
| 关键词 | Bitter melon diabetes mellitus crude extracts phyto-metabolites hypoglycemic mechanism MOMORDICA-CHARANTIA L. 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1 ALPHA-GLUCOSIDASE INHIBITION INSULIN-RESISTANCE ANTIDIABETIC ACTIVITIES GUT MICROBIOTA STRUCTURAL-CHARACTERIZATION PHENOLIC-COMPOUNDS OXIDATIVE STRESS PROTEIN-KINASE |
| ISSN号 | 8755-9129 |
| DOI | 10.1080/87559129.2021.1923733 |
| 英文摘要 | Bitter melon (Momordica charantia) has traditionally been used in the management of diabetes in many countries and territories. However, standardized information on the use of this vegetable as an antidiabetic drug is still very limited. Many animal studies and clinical trials have showed the remarkable effect of bitter melon on diabetes. The research results showed that bitter melon could enhance insulin sensitivity, repair damaged pancreas islet beta-cells and stimulate insulin secretion. What's more, bitter melon could reduce hyperglycemia by regulating intestinal flora, inhibiting glucosidase and amylase, scavenging free radicals, enhancing the activity of AMP-activated protein kinase (AMPK) and increasing expression of peroxisome proliferator-activated receptors (PPARs). In addition, it could also act as the glucagon-like peptide 1 receptor (GLP-1 R) agonist and the 11-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1) inhibitor to exert hypoglycemic effects. Therefore, we will discuss the hypoglycemic mechanisms of crude extracts and different phyto-metabolites derived from bitter melon in the paper. |
| WOS记录号 | WOS:000702674200001 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/73341]  |
| 专题 | 中国科学院昆明植物研究所 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.Chinese Acad Sci, Yunnan Key Lab Nat Med Chem, Kunming, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Gao,Ya,Li,Xian,Huang,Yanjie,et al. Bitter Melon and Diabetes Mellitus[J]. FOOD REVIEWS INTERNATIONAL,2021. |
| APA | Gao,Ya,Li,Xian,Huang,Yanjie,Chen,Jianchao,&Qiu,Minghua.(2021).Bitter Melon and Diabetes Mellitus.FOOD REVIEWS INTERNATIONAL. |
| MLA | Gao,Ya,et al."Bitter Melon and Diabetes Mellitus".FOOD REVIEWS INTERNATIONAL (2021). |
入库方式： OAI收割
来源：昆明植物研究所
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