Macathiohydantoin L, a Novel Thiohydantoin Bearing a Thioxohexahydroimidazo [1,5-a] Pyridine Moiety from Maca (Lepidium meyenii Walp.)
文献类型:期刊论文
作者 | Zhang,Ranran; Liu,Junhong; Yan,Hui; Peng,Xingrong; Zhang,Ling; Qiu,Minghua |
刊名 | MOLECULES |
出版日期 | 2021 |
卷号 | 26期号:16页码:4934 |
ISSN号 | 1420-3049 |
关键词 | Lepidium meyenii thiohydantoins thioxohexahydroimidazo [1 5-a] pyridine neuroprotective activities IMIDAZOLE ALKALOIDS DERIVATIVES EXTRACTION MACAMIDES HYDANTOIN ANALOGS TUBERS |
DOI | 10.3390/molecules26164934 |
英文摘要 | Five new thiohydantoin derivatives (1-5) were isolated from the rhizomes of Lepidium meyenii Walp. NMR (H-1 and C-13 NMR, H-1-H-1 COSY, HSQC, and HMBC), HRESIMS, and ECD were employed for the structure elucidation of new compounds. Significantly, the structure of compound 1 was the first example of thiohydantoins with thioxohexahydroimidazo [1,5-a] pyridine moiety. Additionally, compounds 2 and 3 possess rare disulfide bonds. Except for compound 4, all isolates were assessed for neuroprotective activities in corticosterone (CORT)-stimulated PC12 cell damage. Among them, compound (-)-3 exhibited moderate neuroprotective activity (cell viability: 68.63%, 20 mu M) compared to the positive control desipramine (DIM) (cell viability: 88.49%, 10 mu M). |
WOS记录号 | WOS:000690030400001 |
源URL | [http://ir.kib.ac.cn/handle/151853/73342] |
专题 | 中国科学院昆明植物研究所 |
作者单位 | 1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China |
推荐引用方式 GB/T 7714 | Zhang,Ranran,Liu,Junhong,Yan,Hui,et al. Macathiohydantoin L, a Novel Thiohydantoin Bearing a Thioxohexahydroimidazo [1,5-a] Pyridine Moiety from Maca (Lepidium meyenii Walp.)[J]. MOLECULES,2021,26(16):4934. |
APA | Zhang,Ranran,Liu,Junhong,Yan,Hui,Peng,Xingrong,Zhang,Ling,&Qiu,Minghua.(2021).Macathiohydantoin L, a Novel Thiohydantoin Bearing a Thioxohexahydroimidazo [1,5-a] Pyridine Moiety from Maca (Lepidium meyenii Walp.).MOLECULES,26(16),4934. |
MLA | Zhang,Ranran,et al."Macathiohydantoin L, a Novel Thiohydantoin Bearing a Thioxohexahydroimidazo [1,5-a] Pyridine Moiety from Maca (Lepidium meyenii Walp.)".MOLECULES 26.16(2021):4934. |
入库方式: OAI收割
来源:昆明植物研究所
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