Lepipyrrolins A-B, two new dimeric pyrrole 2-carbaldehyde alkaloids from the tubers of Lepidium meyenii
文献类型：期刊论文
| 作者 | Liu,Jun-Hong; Zhang,Ran-Ran; Peng,Xing-Rong; Ding,Zhong-Tao; Qiu,Ming-Hua
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| 刊名 | BIOORGANIC CHEMISTRY
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| 出版日期 | 2021 |
| 卷号 | 112页码:104834 |
| 关键词 | Lepidium meyenii Pyrrole 2-carbaldehyde alkaloids Dimers Cytotoxicity THIOHYDANTOIN DERIVATIVES STRUCTURAL ELUCIDATION MACA MACAMIDES WALP. PLANT CROP |
| ISSN号 | 0045-2068 |
| DOI | 10.1016/j.bioorg.2021.104834 |
| 英文摘要 | Nine new pyrrole alkaloids, including two undescribed dimeric pyrrole 2-carbaldehyde alkaloids, lepipyrrolins A-B (1-2), seven pyrrole-alkaloid derivatives, macapyrrolins D-J (3-9), along with three known ones (10-12) were isolated from the rhizomes of Lepidium meyenii. Their structures and absolute configurations were demonstrated by extensive spectroscopic data (1D, 2D NMR, HRESIMS), and calculated electronic circular dichroism (ECD) experiment. Compounds 1, 3-12 were tested for their nitric oxide inhibitory effects. Furthermore, compound 1 was evaluated for its cytotoxic activity against five human tumor cell lines (HL-60, SMMC-7221, A549, MCF-7, and SW480) in vitro, and displayed selective cytotoxicity against SMMC-7721 with IC50 value of 16.78 +/- 0.49 mu M. |
| WOS记录号 | WOS:000661873800009 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/73343]  |
| 专题 | 中国科学院昆明植物研究所 |
| 作者单位 | 1.Yunnan Univ, Sch Chem Sci & Technol, Kunming 650091, Yunnan, Peoples R China 2.Zhang, Ran-Ran 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 4.Peng, Xing-Rong 5.[Liu, Jun-Hong |
| 推荐引用方式 GB/T 7714 | Liu,Jun-Hong,Zhang,Ran-Ran,Peng,Xing-Rong,et al. Lepipyrrolins A-B, two new dimeric pyrrole 2-carbaldehyde alkaloids from the tubers of Lepidium meyenii[J]. BIOORGANIC CHEMISTRY,2021,112:104834. |
| APA | Liu,Jun-Hong,Zhang,Ran-Ran,Peng,Xing-Rong,Ding,Zhong-Tao,&Qiu,Ming-Hua.(2021).Lepipyrrolins A-B, two new dimeric pyrrole 2-carbaldehyde alkaloids from the tubers of Lepidium meyenii.BIOORGANIC CHEMISTRY,112,104834. |
| MLA | Liu,Jun-Hong,et al."Lepipyrrolins A-B, two new dimeric pyrrole 2-carbaldehyde alkaloids from the tubers of Lepidium meyenii".BIOORGANIC CHEMISTRY 112(2021):104834. |
入库方式： OAI收割
来源：昆明植物研究所
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