New ent-kaurane diterpenes from the roasted arabica coffee beans and molecular docking to alpha-glucosidase
文献类型：期刊论文
| 作者 | Hu,GuiLin; Peng,XingRong; Dong,Ding; Nian,Yin ; Gao,Ya; Wang,XiaoYuan; Hong,DeFu; Qiu,MingHua
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| 刊名 | FOOD CHEMISTRY
 |
| 出版日期 | 2021 |
| 卷号 | 345页码:128823 |
| 关键词 | Coffea arabica Ent-kaurane diterpene alpha-Glucosidase Molecular docking |
| ISSN号 | 0308-8146 |
| DOI | 10.1016/j.foodchem.2020.128823 |
| 英文摘要 | Ten new (1-10) and five known (11-15) ent-kaurane diterpene derivatives were identified from the roasted beans of coffea arabica. Their structures were established by extensive spectroscopic analysis including 1D, 2D NMR (HSQC, HMBC, COSY, and ROESY), HRESIMS, and X-ray diffraction analysis. Compounds 1-3 were three types of rearranged ent-kaurane diterpenes, and compounds 4 and 5 were diterpene esters with a rare 6-hydroxyhexanoyl at C-17. Compounds 6, 8, 14, and 15 showed moderate inhibitory effect on alpha-glucosidase with IC50 values of 149.92 +/- 2.52, 23.23 +/- 1.03, 54.58 +/- 4.21, 54.16 +/- 3.95 mu M, respectively, compared to the positive control (60.71 +/- 16.45 mu M). The results of activity assay showed that diterpenes with the double bond between C-15 and C-16 exhibited stronger alpha-glucosidase inhibitory activity. Further molecular docking experiments were adopted to discuss the mechanism of activity. |
| WOS记录号 | WOS:000619234800009 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/73346]  |
| 专题 | 中国科学院昆明植物研究所 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Zool, Ion Channel Res & Drug Dev Ctr, Kunming 650223, Yunnan, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 4.Chinese Acad Sci, Kunming Inst Zool, Key Lab Anim Models & Human Dis Mech, Kunming 650223, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Hu,GuiLin,Peng,XingRong,Dong,Ding,et al. New ent-kaurane diterpenes from the roasted arabica coffee beans and molecular docking to alpha-glucosidase[J]. FOOD CHEMISTRY,2021,345:128823. |
| APA | Hu,GuiLin.,Peng,XingRong.,Dong,Ding.,Nian,Yin.,Gao,Ya.,...&Qiu,MingHua.(2021).New ent-kaurane diterpenes from the roasted arabica coffee beans and molecular docking to alpha-glucosidase.FOOD CHEMISTRY,345,128823. |
| MLA | Hu,GuiLin,et al."New ent-kaurane diterpenes from the roasted arabica coffee beans and molecular docking to alpha-glucosidase".FOOD CHEMISTRY 345(2021):128823. |
入库方式： OAI收割
来源：昆明植物研究所
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